Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.

Details

Serval ID
serval:BIB_34F5D1D5B58D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.
Journal
Cell
Author(s)
Tanaka M., Herr W.
ISSN
0092-8674[print], 0092-8674[linking]
Publication state
Published
Issued date
02/1990
Volume
60
Number
3
Pages
375-386
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
The ubiquitous Oct-1 and lymphoid Oct-2 POU homeodomain transcription factors bind to the same DNA sequence but differ in their activation potential. Oct-2 is a positive, negative, or neutral regulator of beta-globin transcription depending on the position and sequence of multimerized binding sites. To activate transcription, Oct-2 relies on two interdependent nonacidic domains, an N-terminal glutamine-rich region and a C-terminal serine-, threonine-, and proline-rich region. Oct-1 also contains a functional glutamine-rich region but fails to activate beta-globin transcription in our assay because the Oct-1 C-terminus is inactive, indicating that differential activation by Oct-1 and Oct-2 is determined by the combination of multiple activation domains. Oct-2 displays a unique phosphorylation pattern that is absent from molecules lacking one or the other activation domain, suggesting the activation domains have a role in inducing protein phosphorylation.
Keywords
Amino Acid Sequence, Base Sequence, DNA-Binding Proteins/metabolism, Gene Expression Regulation, Genetic Vectors, Globins/genetics, Hela Cells/metabolism, Host Cell Factor C1, Humans, Molecular Sequence Data, Octamer Transcription Factor-1, Octamer Transcription Factor-2, Oligonucleotide Probes, Phosphorylation, Promoter Regions, Genetic, Protein Biosynthesis, Transcription Factors/metabolism, Transcription, Genetic, Transcriptional Activation
Pubmed
Web of science
Create date
24/01/2008 15:36
Last modification date
20/08/2019 13:22
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