Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Zimmermann, E.; Ängquist, L.H.; Mirza, S.S.; Zhao, J.H.; Chasman, D.I.; Fischer, K.; Qi, Q.; Smith, A.V.; Thinggaard, M.; Jarczok, M.N.; Nalls, M.A.; Trompet, S.; Timpson, N.J.; Schmidt, B.; Jackson, A.U.; Lyytikäinen, L.P.; Verweij, N.; Mueller-Nurasyid, M.; Vikström, M.; Marques-Vidal, P.; Wong, A.; Meidtner, K.; Middelberg, R.P.; Strawbridge, R.J.; Christiansen, L.; Kyvik, K.O.; Kyvik, K.O.; Hamsten, A.; Jääskeläinen, T.; Tjønneland, A.; Eriksson, J.G.; Whitfield, J.B.; Boeing, H.; Hardy, R.; Vollenweider, P.; Leander, K.; Peters, A.; van der Harst, P.; Kumari, M.; Lehtimäki, T.; Meirhaeghe, A.; Tuomilehto, J.; Jöckel, K.H.; Ben-Shlomo, Y.; Sattar, N.; Baumeister, S.E.; Davey Smith, G.; Casas, J.P.; Houston, D.K.; März, W.; Christensen, K.; Gudnason, V.; Hu, F.B.; Metspalu, A.; Ridker, P.M.; Wareham, N.J.; Loos, R.J.; Tiemeier, H.; Sonestedt, E.; Sørensen, T.I.

doi:10.1111/obr.12263

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Details

Download: BIB_34CF5280131C.P001.pdf (1730.38 [Ko])
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Serval ID

serval:BIB_34CF5280131C

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults.

Journal

Obesity Reviews

Author(s)

Zimmermann E., Ängquist L.H., Mirza S.S., Zhao J.H., Chasman D.I., Fischer K., Qi Q., Smith A.V., Thinggaard M., Jarczok M.N., Nalls M.A., Trompet S., Timpson N.J., Schmidt B., Jackson A.U., Lyytikäinen L.P., Verweij N., Mueller-Nurasyid M., Vikström M., Marques-Vidal P., Wong A., Meidtner K., Middelberg R.P., Strawbridge R.J., Christiansen L., Kyvik K.O., Kyvik K.O., Hamsten A., Jääskeläinen T., Tjønneland A., Eriksson J.G., Whitfield J.B., Boeing H., Hardy R., Vollenweider P., Leander K., Peters A., van der Harst P., Kumari M., Lehtimäki T., Meirhaeghe A., Tuomilehto J., Jöckel K.H., Ben-Shlomo Y., Sattar N., Baumeister S.E., Davey Smith G., Casas J.P., Houston D.K., März W., Christensen K., Gudnason V., Hu F.B., Metspalu A., Ridker P.M., Wareham N.J., Loos R.J., Tiemeier H., Sonestedt E., Sørensen T.I.

Working group(s)

FTO-Mortality Collaborating Group

Contributor(s)

Orho-Melander M., Zillikens C., Ikram A., Hofman A., Luan J., Khaw KT., Rose LM., Läll K., Mägi R., Qi L., Sun Q., Harris TB., Launer LJ., Eiriksdottir G., Kleber ME., Delgado G., Liu Y., Garcia M., Teumer A., Grabe H., Homuth G., Jukema JW., Ford I., de Craen AJ. , Gallacher J., Yarnell J., Mahabadi AA., Nöthen MM., Erbel R., Stringham HM., Boehnke M., Amouyel P., Ferrières J., Arveiler D., Kähönen M., Nikus K., Nieminen T., Sanchez A., Kivimaki M., van Vliet-Ostaptchouk JV. , Hampel R., Thorand B., De Faire U., Nyberg F., Kuh D., Martin NG., Montgomery GW., Heath AC., Madden PA., Osmond C., Pulizzi N., Roswall N., Halkjaer J., Overvad K., Uusitupa M., Kinnunen L., Lindström J., Saramies J., Keinänen-Kiukaanniemi S., Uusitalo H., Hussi E., Baldassarre D., Veglia F., Humphries S., Tremoli E., Heitmann B.

ISSN

1467-789X (Electronic)

ISSN-L

1467-7881

Publication state

Published

Issued date

2015

Peer-reviewed

Oui

Volume

Number

Pages

327-340

Language

english

Notes

Publication types: Journal Article Publication Status: ppublish

Abstract

Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P < 1 × 10(-32) ), WC (n = 152,631; 0.76 cm; 0.68-0.84, P < 1 × 10(-32) ) and FMI (n = 48,192; 0.17 kg m(-2) ; 0.13-0.22, P = 1.0 × 10(-13) ). Cox proportional hazard regression analyses for mortality showed that the hazards ratio (HR) for the minor allele of the FTO SNPs was 1.02 (1.00-1.04, P = 0.097), but the apparent excess risk was eliminated after adjustment for BMI and WC (HR: 1.00; 0.98-1.03, P = 0.662) and for FMI (HR: 1.00; 0.96-1.04, P = 0.932). In conclusion, this study does not support that the FTO SNP is associated with all-cause mortality independently of the adiposity phenotypes.

URN

urn:nbn:ch:serval-BIB_34CF5280131C2

OAI-PMH

oai:serval.unil.ch:BIB_34CF5280131C

DOI

10.1111/obr.12263

Pubmed

25752329

Web of science

000351612400006

Create date

01/05/2015 17:56