Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI.

Détails

ID Serval
serval:BIB_34CE6EDC21F2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Perfusion measurement in brain gliomas with intravoxel incoherent motion MRI.
Périodique
Ajnr. American Journal of Neuroradiology
Auteur(s)
Federau C., Meuli R., O'Brien K., Maeder P., Hagmann P.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
35
Numéro
2
Pages
256-262
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: Intravoxel incoherent motion MRI has been proposed as an alternative method to measure brain perfusion. Our aim was to evaluate the utility of intravoxel incoherent motion perfusion parameters (the perfusion fraction, the pseudodiffusion coefficient, and the flow-related parameter) to differentiate high- and low-grade brain gliomas.
MATERIALS AND METHODS: The intravoxel incoherent motion perfusion parameters were assessed in 21 brain gliomas (16 high-grade, 5 low-grade). Images were acquired by using a Stejskal-Tanner diffusion pulse sequence, with 16 values of b (0-900 s/mm(2)) in 3 orthogonal directions on 3T systems equipped with 32 multichannel receiver head coils. The intravoxel incoherent motion perfusion parameters were derived by fitting the intravoxel incoherent motion biexponential model. Regions of interest were drawn in regions of maximum intravoxel incoherent motion perfusion fraction and contralateral control regions. Statistical significance was assessed by using the Student t test. In addition, regions of interest were drawn around all whole tumors and were evaluated with the help of histograms.
RESULTS: In the regions of maximum perfusion fraction, perfusion fraction was significantly higher in the high-grade group (0.127 ± 0.031) than in the low-grade group (0.084 ± 0.016, P < .001) and in the contralateral control region (0.061 ± 0.011, P < .001). No statistically significant difference was observed for the pseudodiffusion coefficient. The perfusion fraction correlated moderately with dynamic susceptibility contrast relative CBV (r = 0.59). The histograms of the perfusion fraction showed a "heavy-tailed" distribution for high-grade but not low-grade gliomas.
CONCLUSIONS: The intravoxel incoherent motion perfusion fraction is helpful for differentiating high- from low-grade brain gliomas.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/04/2014 15:43
Dernière modification de la notice
20/08/2019 13:21
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