Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.
Details
Request a copy Under indefinite embargo.UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_34AA25DDD16D
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Compassionate Use of Letermovir in a 2-Year-Old Immunocompromised Child With Resistant Cytomegalovirus Disease.
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN
2048-7207 (Electronic)
ISSN-L
2048-7193
Publication state
Published
Issued date
28/02/2020
Peer-reviewed
Oui
Volume
9
Number
1
Pages
96-99
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Little information on the efficacy and pharmacokinetics of letermovir among immunocompromised children is currently available. We describe here the use of letermovir in a 2-year-old immunocompromised child with ganciclovir-resistant cytomegalovirus disease who required extracorporeal membrane oxygenation. Detailed information on therapeutic-drug-monitoring measures and dosage adjustments for letermovir is provided.
Keywords
Acetates/administration & dosage, Acetates/pharmacokinetics, Acetates/therapeutic use, Antiviral Agents/administration & dosage, Antiviral Agents/pharmacokinetics, Antiviral Agents/therapeutic use, Child, Preschool, Compassionate Use Trials, Cytomegalovirus/genetics, Cytomegalovirus/isolation & purification, Cytomegalovirus Infections/drug therapy, Cytomegalovirus Infections/immunology, Cytomegalovirus Infections/virology, DNA, Viral/blood, Dose-Response Relationship, Drug, Drug Monitoring/methods, Extracorporeal Membrane Oxygenation/adverse effects, Fatal Outcome, Female, Ganciclovir/therapeutic use, Hepatitis, Viral, Human/drug therapy, Hepatitis, Viral, Human/immunology, Humans, Immunocompromised Host, Opportunistic Infections/drug therapy, Pneumonia, Viral/drug therapy, Pneumonia, Viral/immunology, Pneumonia, Viral/virology, Polymerase Chain Reaction, Quinazolines/administration & dosage, Quinazolines/pharmacokinetics, Quinazolines/therapeutic use, Treatment Failure, Viral Load, cytomegalovirus disease, cytomegalovirus infection, letermovir, therapeutic drug monitoring
Pubmed
Web of science
Create date
18/06/2019 9:11
Last modification date
21/10/2023 7:07
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