Effects of exercise on the secondary blood markers commonly used to suspect erythropoietin doping.

Details

Serval ID
serval:BIB_349A7FD78816
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of exercise on the secondary blood markers commonly used to suspect erythropoietin doping.
Journal
Clinical Laboratory
Author(s)
Robinson N., Saugy M., Mangin P.
ISSN
1433-6510 (Print)
ISSN-L
1433-6510
Publication state
Published
Issued date
2003
Volume
49
Number
1-2
Pages
57-62
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Numerous trials have reported that some haematological and biochemical parameters could be put together and be used to detect and fight recombinant erythropoietin doping. Unfortunately, none of the studies mentioned the necessity of taking pre-analytical precautions to avoid possible suspicious results coming from major plasma volume changes caused notably by dehydration. Therefore we studied the behaviour of the most common secondary blood markers before and after a strenuous physical activity to find out how reliable these parameters were. The soluble transferrin receptor and the haemoglobin concentrations as well as the haematocrit level increased significantly after effort, whereas the plasma EPO concentration and the reticulocyte count remained constant. On the other hand, if the values were corrected for haemoconcentration, the soluble transferrin receptor concentration remained stable.
Keywords
Adult, Biological Markers/blood, Doping in Sports, Erythropoietin/blood, Exercise/physiology, Hematocrit, Hemoglobins/analysis, Humans, Male, Plasma Volume/physiology, Receptors, Transferrin/blood, Reticulocyte Count, Substance Abuse Detection
Pubmed
Create date
11/09/2011 13:25
Last modification date
20/08/2019 13:21
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