Article: article from journal or magazin.
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice.
Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/JH-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.
Animals, Antigens, CD8/genetics, Antigens, CD8/metabolism, Crosses, Genetic, DNA Replication, Death, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental/immunology, Encephalomyelitis, Autoimmune, Experimental/physiopathology, Female, Interleukin-2/biosynthesis, Male, Mice, Mice, Inbred Strains, Mice, Mutant Strains, Multiple Sclerosis/immunology, Multiple Sclerosis/physiopathology, Reference Values, T-Lymphocytes/immunology, Thymidine/metabolism
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