Detection and Viability of Colorectal Liver Metastases After Neoadjuvant Chemotherapy: A Multiparametric PET/CT-MRI Study.

Détails

ID Serval
serval:BIB_3426E0E322C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Detection and Viability of Colorectal Liver Metastases After Neoadjuvant Chemotherapy: A Multiparametric PET/CT-MRI Study.
Périodique
Clinical nuclear medicine
Auteur(s)
Dunet V., Halkic N., Prior J.O., Anaye A., Meuli R.A., Sempoux C., Denys A., Schmidt S.
ISSN
1536-0229 (Electronic)
ISSN-L
0363-9762
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
42
Numéro
4
Pages
258-263
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article

Résumé
The aim of this study was to compare combined gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced and diffusion-weighted (DW) MRI with IV contrast-enhanced F-FDG PET/CT to detect and assess the viability of colorectal liver metastases (CLMs) after neoadjuvant chemotherapy (NAC).
After NAC, 45 patients with CLMs were prospectively enrolled and underwent combined Gd-EOB-DTPA-enhanced and DW-MRI and contrast-enhanced F-FDG PET/CT. Forty patients subsequently underwent surgery based on intraoperative ultrasound, which served as the reference standard for the presence of CLMs. The number of metastases detected by each technique was then compared. In 69 resected metastases, the SUVmean and SUVmax, mean and maximum target-to-background ratio (TBR), total lesion glycolysis, metabolic tumor volume, and mean and minimum apparent diffusion coefficient (ADC) were examined to identify correlations with the corresponding tumor viability (TV) determined from histological specimens.
Intraoperative ultrasound revealed 153 CLMs, 122 of which were resected. The detection rate of MRI and contrast-enhanced F-FDG PET/CT were similar (P = 0.61). The SUVmax and minimum ADC were negatively correlated (r = -0.34, P = 0.005) on preoperative imaging after NAC. However, TV was significantly correlated with the maximum TBR (r = 0.33, P = 0.006) and mean TBR (r = 0.37, P = 0.002), but not with the minimum ADC (r = -0.02, P = 0.9) or mean ADC (r = 0.01, P = 0.9).
Combined Gd-EOB-DTPA-enhanced and DW-MRI and contrast-enhanced F-FDG PET/CT allow confident detection of CLMs, but only F-FDG PET metrics are associated with TV after NAC.

Mots-clé
Aged, Colorectal Neoplasms/diagnostic imaging, Colorectal Neoplasms/drug therapy, Colorectal Neoplasms/pathology, Contrast Media, Female, Fluorodeoxyglucose F18, Gadolinium DTPA, Humans, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/drug therapy, Liver Neoplasms/secondary, Magnetic Resonance Imaging, Male, Middle Aged, Neoadjuvant Therapy, Positron Emission Tomography Computed Tomography, Radiopharmaceuticals
Pubmed
Web of science
Création de la notice
08/02/2017 15:01
Dernière modification de la notice
20/08/2019 13:20
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