Independent relations of left ventricular structure with the 24-hour urinary excretion of sodium and aldosterone.

Détails

ID Serval
serval:BIB_3417CA67D9C9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Independent relations of left ventricular structure with the 24-hour urinary excretion of sodium and aldosterone.
Périodique
Hypertension
Auteur(s)
Jin Y., Kuznetsova T., Maillard M.P., Richart T., Thijs L., Bochud M., Herregods M.C., Burnier M., Fagard R., Staessen J.A.
ISSN
1524-4563[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
54
Numéro
3
Pages
489-495
Langue
anglais
Résumé
Previous studies reported on the association of left ventricular mass index (LVMI) with urinary sodium or with circulating or urinary aldosterone. We investigated the independent associations of LVMI with the urinary excretion of both sodium and aldosterone. We randomly recruited 317 untreated subjects from a white population (45.1% women; mean age 48.2 years). Measurements included echocardiographic left ventricular (LV) properties, the 24-hour urinary excretion of sodium and aldosterone, plasma renin activity (PRA), and proximal (RNa(prox)) and distal (RNa(dist)) renal sodium reabsorption, assessed from the endogenous lithium clearance. In multivariable-adjusted models, we expressed changes in LVMI per 1-SD increase in the explanatory variables, while accounting for sex, age, systolic blood pressure, and the waist-to-hip ratio. LVMI increased independently with the urinary excretion of both sodium (+2.48 g/m(2); P=0.005) and aldosterone (+2.63 g/m(2); P=0.004). Higher sodium excretion was associated with increased mean wall thickness (MWT: +0.126 mm, P=0.054), but with no change in LV end-diastolic diameter (LVID: +0.12 mm, P=0.64). In contrast, higher aldosterone excretion was associated with higher LVID (+0.54 mm; P=0.017), but with no change in MWT (+0.070 mm; P=0.28). Higher RNa(dist) was associated with lower relative wall thickness (-0.81x10(-2), P=0.017), because of opposite trends in LVID (+0.33 mm; P=0.13) and MWT (-0.130 mm; P=0.040). LVMI was not associated with PRA or RNa(prox.) In conclusion, LVMI independently increased with both urinary sodium and aldosterone excretion. Increased MWT explained the association of LVMI with urinary sodium and increased LVID the association of LVMI with urinary aldosterone.
Mots-clé
Adolescent, Adult, Aged, Aged, 80 and over, Aldosterone/urine, Blood Pressure/physiology, Echocardiography, Female, Heart Ventricles, Humans, Hypertension/pathology, Hypertension/physiopathology, Hypertrophy, Left Ventricular/pathology, Hypertrophy, Left Ventricular/physiopathology, Male, Middle Aged, Multivariate Analysis, Myocardium/pathology, Renin/blood, Sodium/urine, Waist-Hip Ratio, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/10/2009 9:56
Dernière modification de la notice
08/05/2019 16:52
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