Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.

Détails

ID Serval
serval:BIB_33A255F82CDD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis.
Périodique
FEBS Letters
Auteur(s)
Irmler M., Steiner V., Ruegg C., Wajant H., Tschopp J.
ISSN
0014-5793 (Print)
ISSN-L
0014-5793
Statut éditorial
Publié
Date de publication
2000
Volume
468
Numéro
2-3
Pages
129-133
Langue
anglais
Résumé
The activation of the transcription factor NF-kappaB often results in protection against apoptosis. In particular, pro-apoptotic tumor necrosis factor (TNF) signals are blocked by proteins that are induced by NF-kappaB such as TNFR-associated factor 1 (TRAF1). Here we show that TRAF1 is cleaved after Asp-163 when cells are induced to undergo apoptosis by Fas ligand (FasL). The C-terminal cleavage product blocks the induction of NF-kappaB by TNF and therefore functions as a dominant negative (DN) form of TRAF1. Our results suggest that the generation of DN-TRAF1 is part of a pro-apoptotic amplification system to assure rapid cell death.
Mots-clé
Antigens, CD95/physiology, Apoptosis/drug effects, Apoptosis/physiology, Apoptosis Regulatory Proteins, Burkitt Lymphoma, Caspases/metabolism, Cell Line, Fas Ligand Protein, Fibrosarcoma, Humans, Kidney, Membrane Glycoproteins/pharmacology, Membrane Glycoproteins/physiology, NF-kappa B/metabolism, Peptide Fragments/pharmacology, Proteins/antagonists & inhibitors, Proteins/genetics, Receptors, Tumor Necrosis Factor/physiology, Recombinant Proteins/antagonists & inhibitors, Recombinant Proteins/metabolism, Signal Transduction, TNF Receptor-Associated Factor 1, TNF-Related Apoptosis-Inducing Ligand, Transfection, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
08/05/2019 16:50
Données d'usage