IL-17-producing T cells in lung immunity and inflammation.

Détails

ID Serval
serval:BIB_33908D9FE39F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
IL-17-producing T cells in lung immunity and inflammation.
Périodique
Journal of Allergy and Clinical Immunology
Auteur(s)
Nembrini C., Marsland B.J., Kopf M.
ISSN
1097-6825[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
123
Numéro
5
Pages
986-94; quiz 995-6
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
T(H)17 cells are a recently described effector CD4 T-cell subset characterized by the production of IL-17A, IL-17F, and IL-22, which have been implicated in the pathogenesis of several autoimmune diseases. T(H)17 and other IL-17A-producing T cells, including a population of gammadelta T cells and natural killer T cells, have also been associated with the development of skin, intestinal, and lung inflammatory diseases, such as asthma, granulomatous disease, chronic obstructive pulmonary disease, and cystic fibrosis. On the other hand, IL-17-producing T cells play important roles in protective immunity against some bacterial infections, mainly through the recruitment and activation of neutrophils. Thus, their regulation appears to be critical, and excess or deficient IL-17 elaboration leads either to deficient responses or disease. This review will summarize T(H)17 cell differentiation and discuss the host beneficial and detrimental function of IL-17A and related cytokines produced by different subpopulations of T cells.
Mots-clé
Animals, Autoimmune Diseases/immunology, Autoimmune Diseases/metabolism, Bacteria/immunology, Cell Differentiation/immunology, Cytokines/immunology, Cytokines/metabolism, Fungi/immunology, Humans, Hypersensitivity/immunology, Hypersensitivity/metabolism, Inflammation/immunology, Inflammation/metabolism, Interleukin-17/immunology, Interleukin-17/metabolism, Lung/immunology, Lung/metabolism, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism
Pubmed
Web of science
Création de la notice
18/01/2010 14:01
Dernière modification de la notice
03/03/2018 15:48
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