Response of babesiosis to pentamidine therapy

Détails

ID Serval
serval:BIB_337D60988A48
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Response of babesiosis to pentamidine therapy
Périodique
Annals of Internal Medicine
Auteur(s)
Francioli  P. B., Keithly  J. S., Jones  T. C., Brandstetter  R. D., Wolf  D. J.
ISSN
0003-4819 (Print)
Statut éditorial
Publié
Date de publication
03/1981
Volume
94
Numéro
3
Pages
326-30
Notes
Case Reports
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar
Résumé
Three nonsplenectomized patients were infected with Babesia microti. One had fever, abdominal pain suggesting gallbladder disease, and evidence of disseminated intravascular coagulation; another was considered to have lymphoma, partly because two smears for Babesia before admission were negative. All three patients were treated with pentamidine isethionate and improved clinically. Parasites were no longer seen on smears after 5 days of therapy, but Babesia could still be recovered by hamster inoculation 5 weeks after therapy in one of the patients tested, underscoring the need for this test to properly evaluate eradication of the organism. In one patient, pentamidine was stopped after 7 days because of increased creatinine concentration, and this amount of drug appeared adequate to control the parasitemia. Pain at drug injection sites was a major side effect in all three patients. Pentamidine appears to be useful in controlling clinical manifestations of babesiosis and decreasing parasitemia, but it does not eradicate the organism.
Mots-clé
Aged Amidines/*therapeutic use Animals Babesia/isolation & purification Babesiosis/*drug therapy/parasitology/pathology Female Humans Male Middle Aged Pain/chemically induced Pentamidine/adverse effects/*therapeutic use Splenectomy Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 18:07
Dernière modification de la notice
03/03/2018 15:48
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