Precursor-product relationship between vitellogenin and the yolk proteins as derived from the complete sequence of a Xenopus vitellogenin gene.

Détails

ID Serval
serval:BIB_337B931BB904
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Precursor-product relationship between vitellogenin and the yolk proteins as derived from the complete sequence of a Xenopus vitellogenin gene.
Périodique
Nucleic Acids Research
Auteur(s)
Gerber-Huber S., Nardelli D., Haefliger J.A., Cooper D.N., Givel F., Germond J.E., Engel J., Green N.M., Wahli W.
ISSN
0305-1048[print], 0305-1048[linking]
Statut éditorial
Publié
Date de publication
1987
Volume
15
Numéro
12
Pages
4737-4760
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In Xenopus laevis four estrogen-responsive genes are expressed simultaneously to produce vitellogenin, the precursor of the yolk proteins. One of these four genes, the gene A2, was sequenced completely, as well as cDNAs representing 75% of the coding region of the gene. From this data the exon-intron structure of the gene was established, revealing 35 exons that give a transcript of 5,619 bp without the poly A-tail. This A2 transcript encodes a vitellogenin of 1,807 amino acids, whose structure is discussed with respect to its function. At the nucleic acid as well as at the protein level no extensive homologies with any sequences other than vitellogenin were observed. Comparison of the amino acid sequence of the vitellogenin A2 molecule with biochemical data obtained from the different yolk proteins allowed us to localize the cleavage products on the vitellogenin precursor as follows: NH2 - lipovitellin I - phosvitin (or phosvette II - phosvette I) - lipovitellin II - COOH.
Mots-clé
Amino Acid Sequence, Animals, Base Sequence, DNA/genetics, DNA, Recombinant/analysis, Egg Proteins/biosynthesis, Egg Proteins/genetics, Egg Proteins, Dietary, Genes, Multigene Family, Phosvitin/biosynthesis, Phosvitin/genetics, Protein Precursors/genetics, Protein Processing, Post-Translational, Repetitive Sequences, Nucleic Acid, Sequence Homology, Nucleic Acid, Vitellogenins/genetics, Xenopus laevis/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 17:04
Dernière modification de la notice
20/08/2019 14:19
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