The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus.

Détails

ID Serval
serval:BIB_33689
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus.
Périodique
Diabetic Medicine
Auteur(s)
Lacquemant C., Froguel P., Lobbens S., Izzo P., Dina C., Ruiz J.
ISSN
0742-3071
Statut éditorial
Publié
Date de publication
2004
Volume
21
Numéro
7
Pages
776-781
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
BACKGROUND: The ACRP30/adiponectin gene on chromosome 3q27, a region linked to the metabolic syndrome, encodes for the abundant adipocyte-specific secreted protein. Consistent rodent and human studies suggested that this adipokine may be a molecular link between metabolic and cardiovascular diseases. AIMS: In order to investigate the role of single nucleotide polymorphisms (SNPs) within the APM1 gene in the susceptibility to coronary artery disease (CAD), we performed a case-control study on Caucasian Type 2 (non-insulin-dependent) diabetic patients, a population at high-risk for CAD. METHODS: Five APM1 SNPs were genotyped in 162 Type 2 diabetic French and Swiss subjects with CAD and in 315 Type 2 diabetic French and Swiss subjects without CAD. RESULTS: In univariate analysis, SNP+45 T>G was associated with CAD (OR 1.9 95% CI 1.2-2.9 P = 0.0036). In multivariate analysis, SNP+45 T>G remained associated with CAD (OR 1.2 95% CI 0.8-1.9 P = 0.017), independently of classical cardiovascular risk factors including components of the metabolic syndrome. SNP haplotype analyses revealed a CAD protective combination of all SNP wild-type alleles (OR 0.5 95% CI 0.3-0.7 P = 0.0006). CONCLUSIONS: Our study, performed in diabetic subjects, revealed an association between individual SNP+45 in the APM1 gene and CAD. Furthermore, the susceptibility for CAD due to SNP+45 was independent of classic cardiovascular risk factors. Further studies will be necessary to confirm the role of SNP+45 in the development of CAD. However, ACRP30/adiponectin may contribute to atherosclerosis susceptibility in high-risk populations such as Type 2 diabetic subjects.
Mots-clé
Adiponectin, Adult, Aged, Case-Control Studies, Chromosomes, Human, Pair 3/genetics, Coronary Artery Disease/genetics, Diabetes Mellitus, Type 2/genetics, Diabetic Angiopathies/genetics, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Intercellular Signaling Peptides and Proteins, Male, Middle Aged, Polymorphism, Single Nucleotide, Proteins/genetics, Risk Factors
Pubmed
Web of science
Création de la notice
19/11/2007 13:32
Dernière modification de la notice
03/03/2018 15:48
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