The Hypertension Pandemic: An Evolutionary Perspective.

Détails

ID Serval
serval:BIB_3358E9A3943E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The Hypertension Pandemic: An Evolutionary Perspective.
Périodique
Physiology (Bethesda, Md.)
Auteur(s)
Rossier B.C., Bochud M., Devuyst O.
ISSN
1548-9221 (Electronic)
ISSN-L
1548-9221
Statut éditorial
Publié
Date de publication
02/2017
Peer-reviewed
Oui
Volume
32
Numéro
2
Pages
112-125
Langue
anglais
Résumé
Hypertension affects over 1.2 billion individuals worldwide and has become the most critical and expensive public health problem. Hypertension is a multifactorial disease involving environmental and genetic factors together with risk-conferring behaviors. The cause of the disease is identified in ∼10% of the cases (secondary hypertension), but in 90% of the cases no etiology is found (primary or essential hypertension). For this reason, a better understanding of the mechanisms controlling blood pressure in normal and hypertensive patients is the aim of very active experimental and clinical research. In this article, we review the importance of the renin-angiotensin-aldosterone system (RAAS) for the control of blood pressure, focusing on the evolution of the system and its critical importance for adaptation of vertebrates to a terrestrial and dry environment. The evolution of blood pressure control during the evolution of primates, hominins, and humans is discussed, together with the role of common genetic factors and the possible causes of the current hypertension pandemic in the light of evolutionary medicine.

Pubmed
Web of science
Création de la notice
28/02/2017 20:32
Dernière modification de la notice
20/08/2019 13:19
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