Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices.

Details

Serval ID
serval:BIB_3356FE02B52D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices.
Journal
Journal of the American Medical Association
Author(s)
Athan E., Chu V.H., Tattevin P., Selton-Suty C., Jones P., Naber C., Miró J.M., Ninot S., Fernández-Hidalgo N., Durante-Mangoni E., Spelman D., Hoen B., Lejko-Zupanc T., Cecchi E., Thuny F., Hannan M.M., Pappas P., Henry M., Fowler V.G., Crowley A.L., Wang A.
Working group(s)
ICE-PCS Investigators
Contributor(s)
Clara L., Sanchez M., Nacinovich F., Fernandez Oses P., Ronderos R., Sucari A., Thierer J., Casabé J., Cortes C., Altclas J., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley MP., Harkness J., Jones P., Ryan S., Jones P., Ryan S., Jones P., Post J., Reinbott P., Ryan S., Gattringer R., Wiesbauer F., Andrade AR., de Brito£££Ana Cláudia Passos£££ AC. , Guimarães AC., Grinberg M., Mansur AJ., Siciliano RF., Strabelli TM., Vieira ML., Tranchesi RA., Paiva MG., Fortes CQ., Ramos Ade O., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky JA., Keynan Y., Morris AM., Rubinstein E., Braun Jones S., Garcia P., Cereceda M., Fica A., Montagna Mella R., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., El Kholy A., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta JP., Fournier PE., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio PY., Michelet C., Revest M., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Mazaheri B., Naber C., Neuerburg C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Gilon D., Israel S., Korem M., Rubinstein E., Strahilevitz J., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Tripodi MF., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj SS., Yasmine M., Abidin I., Tamin SS., Rivera Martínez E., Soto Nieto GI. , van der Meer JT. , Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch DR., Dragulescu S., Ionac A., Mornos C., Butkevich O., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum LN., Tan RS., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castañeda X., Cervera C., del Río A., Falces C., Garcia-de-la-Maria C., Fita G., Gatell JM., Marco F., Mestres CA., Miró JM., Moreno£££Asunción£££ A. , Ninot S., Paré C., Pericas J., Ramírez J., Rovira I., Sitges M., Anguera I., Font B., Raimon Guma J., Bermejo J., Bouza E., García Fernández MA. , González-Ramallo£££Víctor£££ V. , Marín M., Muñoz P., Pedromingo M., Roda J., Rodríguez-Créixems M., Solís J., Almirante B., Fernández-Hidalgo N., Tornos P., de Alarcón£££Arístides£££ A. , Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein JL., Bradley S., Kauffman C., Bedimo R., Chu VH., Corey G., Crowley AL., Douglas P., Drew L., Fowler VG., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Wang A., Woods CW., Lerakis S., Cantey R., Steed L., Wray D., Dickerman SA., Bonilla H., DiPersio J., Salstrom SJ., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell CH., Baloch K., Chu VH., Corey G., Dixon CC., Fowler VG.<Suffix>Jr</Suffix> , Harding T., Jones-Richmond M., Pappas P., Park LP., Redick T., Stafford J., Anstrom K., Athan E., Bayer AS., Cabell CH., Chu VH., Corey G., Fowler VG.<Suffix>Jr</Suffix> , Hoen B., Karchmer A., Miró JM., Murdoch DR., Sexton DJ., Wang A., Bayer AS., Cabell CH., Chu V., Corey G., Durack DT., Eykyn S., Fowler VG.<Suffix>Jr</Suffix> , Hoen B., Miró JM., Moreillon P., Olaison L., Raoult D., Rubinstein E., Sexton DJ.
ISSN
1538-3598 (Electronic)
ISSN-L
0098-7484
Publication state
Published
Issued date
2012
Volume
307
Number
16
Pages
1727-1735
Language
english
Abstract
CONTEXT: Infection of implantable cardiac devices is an emerging disease with significant morbidity, mortality, and health care costs.
OBJECTIVES: To describe the clinical characteristics and outcome of cardiac device infective endocarditis (CDIE) with attention to its health care association and to evaluate the association between device removal during index hospitalization and outcome.
DESIGN, SETTING, AND PATIENTS: Prospective cohort study using data from the International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS), conducted June 2000 through August 2006 in 61 centers in 28 countries. Patients were hospitalized adults with definite endocarditis as defined by modified Duke endocarditis criteria.
MAIN OUTCOME MEASURES: In-hospital and 1-year mortality.
RESULTS: CDIE was diagnosed in 177 (6.4% [95% CI, 5.5%-7.4%]) of a total cohort of 2760 patients with definite infective endocarditis. The clinical profile of CDIE included advanced patient age (median, 71.2 years [interquartile range, 59.8-77.6]); causation by staphylococci (62 [35.0% {95% CI, 28.0%-42.5%}] Staphylococcus aureus and 56 [31.6% {95% CI, 24.9%-39.0%}] coagulase-negative staphylococci); and a high prevalence of health care-associated infection (81 [45.8% {95% CI, 38.3%-53.4%}]). There was coexisting valve involvement in 66 (37.3% [95% CI, 30.2%-44.9%]) patients, predominantly tricuspid valve infection (43/177 [24.3%]), with associated higher mortality. In-hospital and 1-year mortality rates were 14.7% (26/177 [95% CI, 9.8%-20.8%]) and 23.2% (41/177 [95% CI, 17.2%-30.1%]), respectively. Proportional hazards regression analysis showed a survival benefit at 1 year for device removal during the initial hospitalization (28/141 patients [19.9%] who underwent device removal during the index hospitalization had died at 1 year, vs 13/34 [38.2%] who did not undergo device removal; hazard ratio, 0.42 [95% CI, 0.22-0.82]).
CONCLUSIONS: Among patients with CDIE, the rate of concomitant valve infection is high, as is mortality, particularly if there is valve involvement. Early device removal is associated with improved survival at 1 year.
Keywords
Aged, Cross Infection/etiology, Cross Infection/mortality, Defibrillators, Implantable/adverse effects, Device Removal, Endocarditis/etiology, Endocarditis/mortality, Female, Heart Valve Diseases/etiology, Heart Valve Diseases/mortality, Hospital Mortality/trends, Hospitalization, Humans, Male, Middle Aged, Pacemaker, Artificial/adverse effects, Prevalence, Prospective Studies, Staphylococcal Infections/etiology, Staphylococcal Infections/mortality, Survival Analysis, Treatment Outcome, Tricuspid Valve
Pubmed
Web of science
Open Access
Yes
Create date
06/09/2012 15:29
Last modification date
20/08/2019 13:19
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