Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.

Détails

ID Serval
serval:BIB_32DF0F646EFA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Huang H.Y., Rivas-Caicedo A., Renevey F., Cannelle H., Peranzoni E., Scarpellino L., Hardie D.L., Pommier A., Schaeuble K., Favre S., Vogt T.K., Arenzana-Seisdedos F., Schneider P., Buckley C.D., Donnadieu E., Luther S.A.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
115
Numéro
29
Pages
E6826-E6835
Langue
anglais
Résumé
Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. The early PCs are retained within the reactive lymphoid organ where their localization and homeostasis rely on extrinsic factors, presumably produced by local niche cells. While myeloid cells have been proposed to form those niches, the contribution by colocalizing stromal cells has remained unclear. Here, we characterized a subset of fibroblastic reticular cells (FRCs) that forms a dense meshwork throughout medullary cords of lymph nodes (LNs) where PCs reside. This medullary FRC type is shown to be anatomically, phenotypically, and functionally distinct from T zone FRCs, both in mice and humans. By using static and dynamic imaging approaches, we provide evidence that medullary FRCs are the main cell type in contact with PCs guiding them in their migration. Medullary FRCs also represent a major local source of the PC survival factors IL-6, BAFF, and CXCL12, besides also producing APRIL. In vitro, medullary FRCs alone or in combination with macrophages promote PC survival while other LN cell types do not have this property. Thus, we propose that this FRC subset, together with medullary macrophages, forms PC survival niches within the LN medulla, and thereby helps in promoting the rapid development of humoral immunity, which is critical in limiting early pathogen spread.
Mots-clé
FRC subsets, extrafollicular B cell differentiation, humoral response, lymph node medulla, plasma cell survival
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/08/2018 16:16
Dernière modification de la notice
20/08/2019 13:18
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