AGE-RELATED CHANGES IN CHOROIDAL VASCULAR DENSITY OF HEALTHY SUBJECTS BASED ON IMAGE BINARIZATION OF SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.

Details

Serval ID
serval:BIB_32CE0EF93F98
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
AGE-RELATED CHANGES IN CHOROIDAL VASCULAR DENSITY OF HEALTHY SUBJECTS BASED ON IMAGE BINARIZATION OF SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY.
Journal
Retina
Author(s)
Ruiz-Medrano J., Ruiz-Moreno J.M., Goud A., Vupparaboina K.K., Jana S., Chhablani J.
ISSN
1539-2864 (Electronic)
ISSN-L
0275-004X
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
38
Number
3
Pages
508-515
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To analyze the vascular density of the choroid in a healthy population using swept-source optical coherence tomography.
A cross-sectional, noninterventional study.
best-corrected visual acuity between 20/20 and 20/25, spherical equivalent between ±3 diopters, no systemic or ocular diseases, and ages ranging between 3 and 85 years. One hundred and thirty-six eyes from 136 subjects were analyzed, 86 eyes (63.2%) were from male and 50 eyes (36.8%) from female subjects. The eyes were divided into different age groups to analyze the possible age-related changes. Twelve-millimeter horizontal, fovea-centered B-scans were used. Choroidal stroma and vessel area analysis involved automated segmentation and binarization using validated algorithms.
Mean age was 33.1 ± 24.5 years. Mean choroidal area was 0.5554 ± 0.1377 mm. Mean stromal area was 0.2524 ± 0.0762 mm, and mean vascular region area was 0.3029 ± 0.0893 mm. The percentage of choroidal vascularity (vascular area/total area) was 54.40 ± 8.35%. Choroid area, vascular region, and percentage of choroidal vascular density were statistically higher in the <18-year-old group versus the >18-year-old group (P < 0.001). The stromal region was not different (P = 0.46). In the same way, choroid area, vascular region, and percentage of choroidal vascular density between the 5 age groups were statistically different (P < 0.001), showing larger figures in the 0 to 10-year-old group, but not stromal region (P = 0.71). There were no gender-related differences.
The luminal area and the percentage of vascular/total area decrease with increasing age, while the stromal area remains stable.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Aging/physiology, Child, Child, Preschool, Choroid/blood supply, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Tomography, Optical Coherence/methods, Young Adult
Pubmed
Create date
07/03/2017 19:49
Last modification date
20/08/2019 13:18
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