Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.

Détails

ID Serval
serval:BIB_32B36047428A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Sleep characteristics and cognitive impairment in the general population: The HypnoLaus study.
Périodique
Neurology
Auteur(s)
Haba-Rubio J., Marti-Soler H., Tobback N., Andries D., Marques-Vidal P., Waeber G., Vollenweider P., von Gunten A., Preisig M., Castelao E., Tafti M., Heinzer R., Popp J.
ISSN
1526-632X (Electronic)
ISSN-L
0028-3878
Statut éditorial
Publié
Date de publication
31/01/2017
Peer-reviewed
Oui
Volume
88
Numéro
5
Pages
463-469
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To assess the association between sleep structure and cognitive impairment in the general population.
Data stemmed from 580 participants aged >65 years of the population-based CoLaus/PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home. Cognitive function was evaluated using a comprehensive neuropsychological test battery and a questionnaire on the participant's everyday activities. Participants with cognitive impairment (global Clinical Dementia Rating [CDR] scale score > 0) were compared with participants with no cognitive impairment (global CDR score = 0).
The 291 participants with a CDR score > 0 (72.5 ± 4.6 years), compared to the 289 controls with CDR = 0 (72.1 ± 4.6 years), had significantly more light (stage N1) and less deep (stage N3) and REM sleep, as well as lower sleep efficiency, higher intrasleep wake, and higher sleepiness scores (all p < 0.05). Sleep-disordered breathing was more severe in participants with cognitive impairment with an apnea/hypopnea index (AHI) of 18.0 (7.8-35.5)/h (p50 [p25-p75]) (vs 12.9 [7.2-24.5]/h, p < 0.001), and higher oxygen desaturation index (ODI). In the multivariate analysis after adjustments for confounding variables, the AHI and the ODI ≥4% and ≥6% were independently associated with cognitive impairment.
Participants aged >65 years with cognitive impairment have higher sleepiness scores and a more disrupted sleep. This seems to be related to the occurrence of sleep-disordered breathing and the associated intermittent hypoxia.

Mots-clé
Aged, Cognitive Dysfunction/complications, Cognitive Dysfunction/physiopathology, Follow-Up Studies, Humans, Mental Status Schedule, Multivariate Analysis, Neuropsychological Tests, Polysomnography, Severity of Illness Index, Sleep/physiology, Sleep Wake Disorders/complications, Sleep Wake Disorders/physiopathology, Sleep Wake Disorders/psychology, Surveys and Questionnaires, Switzerland
Pubmed
Création de la notice
05/02/2017 20:10
Dernière modification de la notice
20/08/2019 13:18
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