Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials

Details

Serval ID
serval:BIB_3285FE3A7C6B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials
Journal
Clin Cancer Res
Author(s)
Ferte C., Fernandez M., Hollebecque A., Koscielny S., Levy A., Massard C., Balheda R., Bot B., Gomez-Roca C., Dromain C., Ammari S., Soria J. C.
ISSN-L
1078-0432 (Print)1078-0432 (Linking)
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
20
Number
1
Pages
246-52
Language
english
Notes
Ferte, CharlesFernandez, MariannaHollebecque, AntoineKoscielny, SergeLevy, AntoninMassard, ChristopheBalheda, RastislavBot, BrianGomez-Roca, CarlosDromain, ClarisseAmmari, SamySoria, Jean-CharlesengU54 CA149237/CA/NCI NIH HHS/U54CA149237/CA/NCI NIH HHS/Research Support, N.I.H., Extramural2013/11/19 06:00Clin Cancer Res. 2014 Jan 1;20(1):246-52. doi: 10.1158/1078-0432.CCR-13-2098. Epub 2013 Nov 15.
Abstract
PURPOSE: Response Evaluation Criteria in Solid Tumors (RECIST) evaluation does not take into account the pretreatment tumor kinetics and may provide incomplete information about experimental drug activity. Tumor growth rate (TGR) allows for a dynamic and quantitative assessment of the tumor kinetics. How TGR varies along the introduction of experimental therapeutics and is associated with outcome in phase I patients remains unknown. EXPERIMENTAL DESIGN: Medical records from all patients (N = 253) prospectively treated in 20 phase I trials were analyzed. TGR was computed during the pretreatment period (reference) and the experimental period. Associations between TGR, standard prognostic scores [Royal Marsden Hospital (RMH) score], and outcome [progression-free survival (PFS) and overall survival (OS)] were computed (multivariate analysis). RESULTS: We observed a reduction of TGR between the reference versus experimental periods (38% vs. 4.4%; P < 0.00001). Although most patients were classified as stable disease (65%) or progressive disease (25%) by RECIST at the first evaluation, 82% and 65% of them exhibited a decrease in TGR, respectively. In a multivariate analysis, only the decrease of TGR was associated with PFS (P = 0.004), whereas the RMH score was the only variable associated with OS (P = 0.0008). Only the investigated regimens delivered were associated with a decrease of TGR (P < 0.00001, multivariate analysis). Computing TGR profiles across different clinical trials reveals specific patterns of antitumor activity. CONCLUSIONS: Exploring TGR in phase I patients is simple and provides clinically relevant information: (i) an early and subtle assessment of signs of antitumor activity; (ii) independent association with PFS; and (iii) it reveals drug-specific profiles, suggesting potential utility for guiding the further development of the investigational drugs.
Keywords
Adult, Aged, Antineoplastic Agents/pharmacology/*therapeutic use, Cell Proliferation, Clinical Trials, Phase I as Topic, Female, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasms/*drug therapy/pathology, Proportional Hazards Models, Prospective Studies, Treatment Outcome, Tumor Burden/drug effects, Young Adult
Open Access
Yes
Create date
16/09/2016 11:14
Last modification date
20/08/2019 14:18
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