Immunolocalization of neuropeptide Y in human pituitary tumours.

Details

Serval ID
serval:BIB_3270A4417F62
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunolocalization of neuropeptide Y in human pituitary tumours.
Journal
Regulatory peptides
Author(s)
Grouzmann E., Deruaz J.P., Gomez F., Waeber G.
ISSN
0167-0115
Publication state
Published
Issued date
1998
Peer-reviewed
Oui
Volume
75-76
Pages
89-92
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Neuropeptide Y (NPY) gene is expressed in human pituitary gland where its function is partially elucidated. NPY could act as a neuroendocrine modulator within this gland. This study was undertaken to assess whether NPY expression is correlated to various pathological situations. Using a highly specific anti-NPY monoclonal antibody, immunohistochemistry analysis was performed in surgically removed pituitary glands. The study included biopsies from 112 human pituitary adenomas, 12 hyperplastic glands and normal anterior pituitary tissues in 34 cases. NPY is immunodetected in 33% of all adenomas, 25% hyperplastic glands and 12% of non-tumoral pituitary gland. NPY expression was significantly higher in adenomas compared to the normal gland. However, no correlation was observed between NPY content and the type of hormonal secretion, sex, age and the status of tumour proliferating potential.
Keywords
Adenoma, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Child, Child, Preschool, Female, Gonadotropins, Pituitary, Human Growth Hormone, Humans, Hyperplasia, Immunohistochemistry, Infant, Male, Middle Aged, Neuropeptide Y, Pituitary Gland, Anterior, Pituitary Neoplasms
Pubmed
Web of science
Create date
25/01/2008 14:10
Last modification date
20/08/2019 13:18
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