Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy.

Détails

ID Serval
serval:BIB_3265601445AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy.
Périodique
Annals of Neurology
Auteur(s)
Brefel-Courbon C., Payoux P., Ory F., Sommet A., Slaoui T., Raboyeau G., Lemesle B., Puel M., Montastruc J.L., Demonet J.F., Cardebat D.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
62
Numéro
1
Pages
102-105
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled TrialPublication Status: ppublish. PDF type: Brief Communication
Résumé
We conducted a randomized, double-blind, placebo-controlled, single-patient (N = 1) trial to evaluate the efficacy of zolpidem in a 48-year-old woman with an akinetic mutism. Motor and cognitive examinations and functional imaging were performed. Acute administration of zolpidem markedly improved motor performance and neuropsychological status. Cerebral metabolism ((18)F-fluorodeoxyglucose positron emission tomography) increased in postrolandic territories and in frontal cortex. Using the H(2) (15)O positron emission tomography, we found a drug-induced activation in the anterior cingulate and orbitofrontal cortices. Zolpidem induced a transient improvement in motor and cognitive performances. This paradoxical effect could result from an activation of limbic loops modulating motivational processes.
Mots-clé
Double-Blind Method, Female, Fluorodeoxyglucose F18/pharmacokinetics, GABA Agonists/therapeutic use, Humans, Hypoxia, Brain/drug therapy, Hypoxia, Brain/radionuclide imaging, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Pyridines/therapeutic use
Pubmed
Web of science
Création de la notice
24/03/2013 19:54
Dernière modification de la notice
03/03/2018 15:43
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