Article: article from journal or magazin.
Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy.
Annals of Neurology
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled TrialPublication Status: ppublish. PDF type: Brief Communication
We conducted a randomized, double-blind, placebo-controlled, single-patient (N = 1) trial to evaluate the efficacy of zolpidem in a 48-year-old woman with an akinetic mutism. Motor and cognitive examinations and functional imaging were performed. Acute administration of zolpidem markedly improved motor performance and neuropsychological status. Cerebral metabolism ((18)F-fluorodeoxyglucose positron emission tomography) increased in postrolandic territories and in frontal cortex. Using the H(2) (15)O positron emission tomography, we found a drug-induced activation in the anterior cingulate and orbitofrontal cortices. Zolpidem induced a transient improvement in motor and cognitive performances. This paradoxical effect could result from an activation of limbic loops modulating motivational processes.
Double-Blind Method, Female, Fluorodeoxyglucose F18/pharmacokinetics, GABA Agonists/therapeutic use, Humans, Hypoxia, Brain/drug therapy, Hypoxia, Brain/radionuclide imaging, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Pyridines/therapeutic use
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