Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Wain, L.V.; Vaez, A.; Jansen, R.; Joehanes, R.; van der Most, P.J.; Erzurumluoglu, A.M.; O'Reilly, P.F.; Cabrera, C.P.; Warren, H.R.; Rose, L.M.; Verwoert, G.C.; Hottenga, J.J.; Strawbridge, R.J.; Esko, T.; Arking, D.E.; Hwang, S.J.; Guo, X.; Kutalik, Z.; Trompet, S.; Shrine, N.; Teumer, A.; Ried, J.S.; Bis, J.C.; Smith, A.V.; Amin, N.; Nolte, I.M.; Lyytikäinen, L.P.; Mahajan, A.; Wareham, N.J.; Hofer, E.; Joshi, P.K.; Kristiansson, K.; Traglia, M.; Havulinna, A.S.; Goel, A.; Nalls, M.A.; Sõber, S.; Vuckovic, D.; Luan, J.; Del Greco M, F.; Ayers, K.L.; Marrugat, J.; Ruggiero, D.; Lopez, L.M.; Niiranen, T.; Enroth, S.; Jackson, A.U.; Nelson, C.P.; Huffman, J.E.; Zhang, W.; Marten, J.; Gandin, I.; Harris, S.E.; Zemunik, T.; Lu, Y.; Evangelou, E.; Shah, N.; de Borst, M.H.; Mangino, M.; Prins, B.P.; Campbell, A.; Li-Gao, R.; Chauhan, G.; Oldmeadow, C.; Abecasis, G.; Abedi, M.; Barbieri, C.M.; Barnes, M.R.; Batini, C.; Beilby, J.; Blake, T.; Boehnke, M.; Bottinger, E.P.; Braund, P.S.; Brown, M.; Brumat, M.; Campbell, H.; Chambers, J.C.; Cocca, M.; Collins, F.; Connell, J.; Cordell, H.J.; Damman, J.J.; Davies, G.; de Geus, E.J.; de Mutsert, R.; Deelen, J.; Demirkale, Y.; Doney, ASF; Dörr, M.; Farrall, M.; Ferreira, T.; Frånberg, M.; Gao, H.; Giedraitis, V.; Gieger, C.; Giulianini, F.; Gow, A.J.; Hamsten, A.; Harris, T.B.; Hofman, A.; Holliday, E.G.; Hui, J.; Jarvelin, M.R.; Johansson, Å.; Johnson, A.D.; Jousilahti, P.; Jula, A.; Kähönen, M.; Kathiresan, S.; Khaw, K.T.; Kolcic, I.; Koskinen, S.; Langenberg, C.; Larson, M.; Launer, L.J.; Lehne, B.; Liewald, DCM; Lin, L.; Lind, L.; Mach, F.; Mamasoula, C.; Menni, C.; Mifsud, B.; Milaneschi, Y.; Morgan, A.; Morris, A.D.; Morrison, A.C.; Munson, P.J.; Nandakumar, P.; Nguyen, Q.T.; Nutile, T.; Oldehinkel, A.J.; Oostra, B.A.; Org, E.; Padmanabhan, S.; Palotie, A.; Paré, G.; Pattie, A.; Penninx, BWJH; Poulter, N.; Pramstaller, P.P.; Raitakari, O.T.; Ren, M.; Rice, K.; Ridker, P.M.; Riese, H.; Ripatti, S.; Robino, A.; Rotter, J.I.; Rudan, I.; Saba, Y.; Saint Pierre, A.; Sala, C.F.; Sarin, A.P.; Schmidt, R.; Scott, R.; Seelen, M.A.; Shields, D.C.; Siscovick, D.; Sorice, R.; Stanton, A.; Stott, D.J.; Sundström, J.; Swertz, M.; Taylor, K.D.; Thom, S.; Tzoulaki, I.; Tzourio, C.; Uitterlinden, A.G.; Völker, U.; Vollenweider, P.; Wild, S.; Willemsen, G.; Wright, A.F.; Yao, J.; Thériault, S.; Conen, D.; Attia, J.; Sever, P.; Debette, S.; Mook-Kanamori, D.O.; Zeggini, E.; Spector, T.D.; van der Harst, P.; Palmer, CNA; Vergnaud, A.C.; Loos, RJF; Polasek, O.; Starr, J.M.; Girotto, G.; Hayward, C.; Kooner, J.S.; Lindgren, C.M.; Vitart, V.; Samani, N.J.; Tuomilehto, J.; Gyllensten, U.; Knekt, P.; Deary, I.J.; Ciullo, M.; Elosua, R.; Keavney, B.D.; Hicks, A.A.; Scott, R.A.; Gasparini, P.; Laan, M.; Liu, Y.; Watkins, H.; Hartman, C.A.; Salomaa, V.; Toniolo, D.; Perola, M.; Wilson, J.F.; Schmidt, H.; Zhao, J.H.; Lehtimäki, T.; van Duijn, C.M.; Gudnason, V.; Psaty, B.M.; Peters, A.; Rettig, R.; James, A.; Jukema, J.W.; Strachan, D.P.; Palmas, W.; Metspalu, A.; Ingelsson, E.; Boomsma, D.I.; Franco, O.H.; Bochud, M.; Newton-Cheh, C.; Munroe, P.B.; Elliott, P.; Chasman, D.I.; Chakravarti, A.; Knight, J.; Morris, A.P.; Levy, D.; Tobin, M.D.; Snieder, H.; Caulfield, M.J.; Ehret, G.B.

doi:10.1161/HYPERTENSIONAHA.117.09438

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

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Serval ID

serval:BIB_324C28AFCA02

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Journal

Hypertension

Author(s)

Wain L.V., Vaez A., Jansen R., Joehanes R., van der Most P.J., Erzurumluoglu A.M., O'Reilly P.F., Cabrera C.P., Warren H.R., Rose L.M., Verwoert G.C., Hottenga J.J., Strawbridge R.J., Esko T., Arking D.E., Hwang S.J., Guo X., Kutalik Z., Trompet S., Shrine N., Teumer A., Ried J.S., Bis J.C., Smith A.V., Amin N., Nolte I.M., Lyytikäinen L.P., Mahajan A., Wareham N.J., Hofer E., Joshi P.K., Kristiansson K., Traglia M., Havulinna A.S., Goel A., Nalls M.A., Sõber S., Vuckovic D., Luan J., Del Greco M F., Ayers K.L., Marrugat J., Ruggiero D., Lopez L.M., Niiranen T., Enroth S., Jackson A.U., Nelson C.P., Huffman J.E., Zhang W., Marten J., Gandin I., Harris S.E., Zemunik T., Lu Y., Evangelou E., Shah N., de Borst M.H., Mangino M., Prins B.P., Campbell A., Li-Gao R., Chauhan G., Oldmeadow C., Abecasis G., Abedi M., Barbieri C.M., Barnes M.R., Batini C., Beilby J., Blake T., Boehnke M., Bottinger E.P., Braund P.S., Brown M., Brumat M., Campbell H., Chambers J.C., Cocca M., Collins F., Connell J., Cordell H.J., Damman J.J., Davies G., de Geus E.J., de Mutsert R., Deelen J., Demirkale Y., Doney ASF, Dörr M., Farrall M., Ferreira T., Frånberg M., Gao H., Giedraitis V., Gieger C., Giulianini F., Gow A.J., Hamsten A., Harris T.B., Hofman A., Holliday E.G., Hui J., Jarvelin M.R., Johansson Å., Johnson A.D., Jousilahti P., Jula A., Kähönen M., Kathiresan S., Khaw K.T., Kolcic I., Koskinen S., Langenberg C., Larson M., Launer L.J., Lehne B., Liewald DCM, Lin L., Lind L., Mach F., Mamasoula C., Menni C., Mifsud B., Milaneschi Y., Morgan A., Morris A.D., Morrison A.C., Munson P.J., Nandakumar P., Nguyen Q.T., Nutile T., Oldehinkel A.J., Oostra B.A., Org E., Padmanabhan S., Palotie A., Paré G., Pattie A., Penninx BWJH, Poulter N., Pramstaller P.P., Raitakari O.T., Ren M., Rice K., Ridker P.M., Riese H., Ripatti S., Robino A., Rotter J.I., Rudan I., Saba Y., Saint Pierre A., Sala C.F., Sarin A.P., Schmidt R., Scott R., Seelen M.A., Shields D.C., Siscovick D., Sorice R., Stanton A., Stott D.J., Sundström J., Swertz M., Taylor K.D., Thom S., Tzoulaki I., Tzourio C., Uitterlinden A.G., Völker U., Vollenweider P., Wild S., Willemsen G., Wright A.F., Yao J., Thériault S., Conen D., Attia J., Sever P., Debette S., Mook-Kanamori D.O., Zeggini E., Spector T.D., van der Harst P., Palmer CNA, Vergnaud A.C., Loos RJF, Polasek O., Starr J.M., Girotto G., Hayward C., Kooner J.S., Lindgren C.M., Vitart V., Samani N.J., Tuomilehto J., Gyllensten U., Knekt P., Deary I.J., Ciullo M., Elosua R., Keavney B.D., Hicks A.A., Scott R.A., Gasparini P., Laan M., Liu Y., Watkins H., Hartman C.A., Salomaa V., Toniolo D., Perola M., Wilson J.F., Schmidt H., Zhao J.H., Lehtimäki T., van Duijn C.M., Gudnason V., Psaty B.M., Peters A., Rettig R., James A., Jukema J.W., Strachan D.P., Palmas W., Metspalu A., Ingelsson E., Boomsma D.I., Franco O.H., Bochud M., Newton-Cheh C., Munroe P.B., Elliott P., Chasman D.I., Chakravarti A., Knight J., Morris A.P., Levy D., Tobin M.D., Snieder H., Caulfield M.J., Ehret G.B.

ISSN

1524-4563 (Electronic)

ISSN-L

0194-911X

Publication state

Published

Issued date

24/07/2017

Peer-reviewed

Oui

Volume

Number

Pages

Language

english

Notes

Publication types: Journal Article

Abstract

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

Keywords

GWAS, blood pressure, cardiovascular risk, complex traits, eSNP, hypertension

OAI-PMH

oai:serval.unil.ch:BIB_324C28AFCA02

DOI

10.1161/HYPERTENSIONAHA.117.09438

Pubmed

28739976

Web of science

000407241500001

Open Access

Yes