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Radiosensitizing and repair-inhibiting properties of dipyridamole
Radiotherapy and Oncology
Journal Article --- Old month value: Aug
Radioresistance and postirradiation repair of potentially lethal damage (PLD repair) are important factors underlying failure to control local disease in cancer. Dipyridamole (DP) is known as a modifier of the action of cytotoxic drugs. We therefore investigated DP as a potential radiosensitizer and inhibitor of PLD repair in X-irradiated Chinese hamster ovary (CHO) cells in vitro. Exposure to the drug alone resulted in a slight reduction of the clonogenic capacity of the cells. Preincubation for 18 h with 10 and 20 microM DP in cells subcultured at low density, led to a significant radiosensitization. In confluent density-inhibited cultures, preincubation alone as well as pre- and postincubation with 20 microM DP resulted in a significant inhibition of PLD repair. Dipyridamole and related compounds may thus be useful tools for modifying and investigating the response of mammalian cells to radiation.
Animals Cell Count Cell Line Cell Survival/drug effects/radiation effects Cricetinae *DNA Damage DNA Repair/*drug effects Dipyridamole/*pharmacology Dose-Response Relationship, Drug Female Ovary/cytology/drug effects/radiation effects Radiation-Sensitizing Agents/*pharmacology
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