Temperature dependence of viscosity, relaxation times (T1, T2) and simulated contrast for potential perfusates in post-mortem MR angiography (PMMRA).

Détails

Ressource 1Télécharger: 27900508.pdf (846.44 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_31D51FAA8496
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Temperature dependence of viscosity, relaxation times (T1, T2) and simulated contrast for potential perfusates in post-mortem MR angiography (PMMRA).
Périodique
International journal of legal medicine
Auteur(s)
Webb B., Widek T., Neumayer B., Bruguier C., Scheicher S., Sprenger H., Grabherr S., Schwark T., Stollberger R.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
05/2017
Peer-reviewed
Oui
Volume
131
Numéro
3
Pages
739-749
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Developments in post-mortem imaging increasingly focus on addressing recognised diagnostic weaknesses, especially with regard to suspected natural deaths. Post-mortem MR angiography (PMMRA) may offer additional diagnostic information to help address such weaknesses, specifically in the context of sudden cardiac death. Complete filling of the coronary arteries and acceptable contrast with surrounding tissue are essential for a successful approach to PMMRA. In this work, the suitability of different liquids for inclusion in a targeted PMMRA protocol was evaluated. Factors influencing cooling of paraffinum liquidum + Angiofil® (6 %) in cadavers during routine multiphase post-mortem CT angiography were investigated. The temperature dependence of dynamic viscosity (8-20 °C), longitudinal (T1) and transverse (T2) relaxation (1-23 °C) of the proposed liquids was quadratically modelled. The relaxation behaviour of these liquids and MR scan parameters were further investigated by simulation of a radiofrequency (RF)-spoiled gradient echo (GRE) sequence to estimate potentially achievable contrast between liquids and post-mortem tissue at different temperatures across a forensically relevant temperature range. Analysis of the established models and simulations indicated that based on dynamic viscosity (27-33 mPa · s), short T1 relaxation times (155-207 ms) and a minimal temperature dependence over the investigated range of these parameters, paraffin oil and a solution of paraffin oil + Angiofil® (6 %) would be most suitable for post-mortem reperfusion and examination in MRI.

Mots-clé
Adult, Aged, Body Temperature, Cadaver, Contrast Media/chemistry, Female, Forensic Pathology, Humans, Magnetic Resonance Angiography, Male, Middle Aged, Oils, Paraffin, Temperature, Viscosity, Young Adult, Angiography, MRI, Post-mortem, Quantitative, Simulation
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/12/2016 16:09
Dernière modification de la notice
08/05/2019 16:43
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