CDK4, a new metabolic sensor that antagonizes AMPK.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_31B3469F93CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CDK4, a new metabolic sensor that antagonizes AMPK.
Périodique
Molecular & cellular oncology
Auteur(s)
Fajas L., Lopez-Mejia I.C.
ISSN
2372-3556 (Print)
ISSN-L
2372-3556
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
5
Numéro
5
Pages
e1409862
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase).
Mots-clé
AMPK, CDK4, Cell Cycle, Fatty acid oxidation, Metabolism, Tumor metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/11/2018 17:20
Dernière modification de la notice
21/08/2019 7:08
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