Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: a systematic review and meta-analysis of the pertinent literature.

Details

Serval ID
serval:BIB_3128DE460915
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: a systematic review and meta-analysis of the pertinent literature.
Journal
European journal of surgical oncology
Author(s)
Kadkhodayan S., Hasanzadeh M., Treglia G., Azad A., Yousefi Z., Zarifmahmoudi L., Sadeghi R.
ISSN
1532-2157 (Electronic)
ISSN-L
0748-7983
Publication state
Published
Issued date
01/2015
Peer-reviewed
Oui
Volume
41
Number
1
Pages
1-20
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
We reviewed the available literature on the accuracy of sentinel node mapping in the lymph nodal staging of uterine cervical cancers.
MEDLINE and Scopus were searched by using "sentinel AND (cervix OR cervical)" as key words. Studies evaluating the accuracy of sentinel node mapping in the lymph nodal staging of uterine cervical cancers were included if enough data could be extracted for calculation of detection rate and/or sensitivity.
Sixty-seven studies were included in the systematic review. Pooled detection rate was 89.2% [95% CI: 86.3-91.6]. Pooled sensitivity was 90% [95% CI: 88-92]. Sentinel node detection rate and sensitivity were related to mapping method (blue dye, radiotracer, or both) and history of pre-operative neoadjuvant chemotherapy. Sensitivity was higher in patients with bilaterally detected pelvic sentinel nodes compared to those with unilateral sentinel nodes. Lymphatic mapping could identify sentinel nodes outside the routine lymphadenectomy limits.
Sentinel node mapping is an accurate method for the assessment of lymph nodal involvement in uterine cervical cancers. Selection of a population with small tumor size and lower stage will ensure the lowest false negative rate. Lymphatic mapping can also detect sentinel nodes outside of routine lymphadenectomy areas providing additional histological information which can improve the staging. Further studies are needed to explore the impact of sentinel node mapping in fertility sparing surgery and in patients with history of neoadjuvant chemotherapy.

Keywords
Adenocarcinoma/pathology, Adenocarcinoma/surgery, Carcinoma, Squamous Cell/pathology, Carcinoma, Squamous Cell/surgery, Female, Humans, Lymph Node Excision, Lymph Nodes/pathology, Lymphatic Metastasis, Neoplasm Staging, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/surgery, Cervical cancer, Evidence based, Lymphatic mapping, Meta-analysis, Sentinel node
Pubmed
Web of science
Create date
20/08/2017 18:17
Last modification date
20/08/2019 14:16
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