Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

Détails

ID Serval
serval:BIB_30F06BA65EA3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.
Périodique
Molecular & cellular oncology
Auteur(s)
Demarco B., Chen K.W., Broz P.
ISSN
2372-3556 (Print)
ISSN-L
2372-3556
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
6
Numéro
4
Pages
1610324
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly. We further demonstrate that differential cleavage of gasdermin D (GSDMD) by apoptotic caspases regulates inflammatory cell lysis. Here, we discuss our findings and perspectives for future studies.
Mots-clé
Apoptosis, Gasdermins, NLRP3 inflammasome, inflammation, pannexin
Pubmed
Financement(s)
Conseil Européen de la Recherche (ERC) / 770988
Création de la notice
22/05/2019 14:03
Dernière modification de la notice
21/08/2019 6:33
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