Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.

Détails

ID Serval
serval:BIB_30A0E673D19C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Insulinoma associated with a case of multiple endocrine neoplasia type I: Functional somatostatin receptors and abnormal glucose-induced insulin secretion.
Périodique
Hormone research
Auteur(s)
Waeber G., Gomez F., Bishof-Delaloye A., Chaubert P., Francke M.L., Haefliger J.A., Scherrer U., Centeno G., Temler E., Nicod P.
ISSN
0301-0163
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
48
Numéro
2
Pages
76-82
Langue
anglais
Notes
Publication types: Case Reports ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
A sporadic case of multiple endocrine neoplasia type I with coexisting insulinoma and hyperparathyroidism was investigated in vivo and in vitro. The insulinoma was localized by somatostatin receptor scintigraphy and these receptors were functionally active. Octreotide administration decreased the basal insulin and glucagon secretion by 90 and 46%, respectively. Immunocytochemistry of the insulinoma tissue was positive for insulin, chromogranin A and neuropeptide Y. The insulinoma cells were also isolated and cultured in vitro. Incubation experiments revealed that a low glucose concentration (1 mmol/l) was sufficient to increase cytosolic free calcium and to produce a maximal glucose-induced insulin release. Northern blot analysis of RNA obtained from the tumor showed a high abundance of the low Km glucose transporter GLUT1 but no transcript for the high Km glucose transporter GLUT2. The abnormal distribution of glucose transporters probably relates to the abnormal glucose sensing of insulinoma cells, and explains their sustained insulin secretion at low glucose concentrations. Whether these abnormalities share a pathogenetic link with the presence of functionally active somatostatin receptors remains to be elucidated.
Mots-clé
Actins, Adolescent, Dose-Response Relationship, Drug, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Glucagon, Glucose, Glucose Transporter Type 1, Hormones, Humans, Hyperparathyroidism, Immunohistochemistry, Injections, Intravenous, Insulin, Insulinoma, Male, Monosaccharide Transport Proteins, Multiple Endocrine Neoplasia Type 1, Octreotide, Pancreatic Neoplasms, Parathyroid Neoplasms, RNA, Messenger, Receptors, Somatostatin, Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
17/11/2008 9:57
Dernière modification de la notice
20/08/2019 14:15
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