Stereotactic lung reirradiation for local relapse: A case series.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_306A219BD9DC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stereotactic lung reirradiation for local relapse: A case series.
Journal
Clinical and translational radiation oncology
Author(s)
Kinj R., Casutt A., Bennassi A., Bouchaab H., Vallet V., Lovis A., Ozsahin M.
ISSN
2405-6308 (Electronic)
ISSN-L
2405-6308
Publication state
Published
Issued date
05/2021
Peer-reviewed
Oui
Volume
28
Pages
85-87
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Local recurrence after lung SBRT for early stage NSCLC is rare but its treatment remains a challenge due to limited surgical options. We report a case series of 5 patients treated by stereotactic lung salvage reirradiation for local relapse after a previous lung SBRT.
Included patients presented an isolated primary lung relapse within at least the 50% isodose of the previous SBRT treatment. Typical reirradiation schedule was 60 Gy in 8 fractions at isodose 80% and was delivered by Cyberknife® using Synchrony® fiducial tracking system. Dose summations were performed to evaluate the safety of the reirradiation.
We identified 5 patients presenting peripheral lesions. All reirradiated lesions were locally controlled after a median follow-up of 11.1 months (6,7-12,2), while PFS at 6 months was 60% (n = 3). We did not notice any Grade 3 or more acute or late adverse event.
We observed encouraging short-term outcome of lung SBRT reirradiation in patients presenting isolated local relapse of an early-stage NSCLC. Further studies are necessary to confirm the safety and efficiency of this salvage treatment approach.
Keywords
Lung cancer, Lung reirradiation, SBRT reirradiation, Stereotactic treatment
Pubmed
Web of science
Open Access
Yes
Create date
19/05/2021 13:05
Last modification date
16/07/2021 6:08
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