Demyelination in mild cognitive impairment suggests progression path to Alzheimer's disease.

Détails

Ressource 1Télécharger: BIB_305275D7E854.P001.pdf (3215.91 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_305275D7E854
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Demyelination in mild cognitive impairment suggests progression path to Alzheimer's disease.
Périodique
Plos One
Auteur(s)
Carmeli C., Donati A., Antille V., Viceic D., Ghika J., von Gunten A., Clarke S., Meuli R., Frackowiak R.S., Knyazeva M.G.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
8
Numéro
8
Pages
e72759
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: epublish
Résumé
The preclinical Alzheimer's disease (AD) - amnestic mild cognitive impairment (MCI) - is manifested by phenotypes classified into exclusively memory (single-domain) MCI (sMCI) and multiple-domain MCI (mMCI). We suggest that typical MCI-to-AD progression occurs through the sMCI-to-mMCI sequence as a result of the extension of initial pathological processes. To support this hypothesis, we assess myelin content with a Magnetization Transfer Ratio (MTR) in 21 sMCI and 21 mMCI patients and in 42 age-, sex-, and education-matched controls. A conjunction analysis revealed MTR reduction shared by sMCI and mMCI groups in the medial temporal lobe and posterior structures including white matter (WM: splenium, posterior corona radiata) and gray matter (GM: hippocampus; parahippocampal and lingual gyri). A disjunction analysis showed the spread of demyelination to prefrontal WM and insula GM in executive mMCI. Our findings suggest that demyelination starts in the structures affected by neurofibrillary pathology; its presence correlates with the clinical picture and indicates the method of MCI-to-AD progression. In vivo staging of preclinical AD can be developed in terms of WM/GM demyelination.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/09/2013 13:23
Dernière modification de la notice
20/08/2019 13:15
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