Pneumopathie interstitielle dans la ­polyarthrite rhumatoïde : nouvelles données génétiques et perspectives thérapeutiques [Rheumatoid arthritis-associated interstitial lung disease : new genetic data and therapeutic perspectives]

Détails

ID Serval
serval:BIB_3052243319A6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pneumopathie interstitielle dans la ­polyarthrite rhumatoïde : nouvelles données génétiques et perspectives thérapeutiques [Rheumatoid arthritis-associated interstitial lung disease : new genetic data and therapeutic perspectives]
Périodique
Revue medicale suisse
Auteur(s)
Valerio F., Daccord C., Letovanec I., Hügle T., Lazor R.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Statut éditorial
Publié
Date de publication
06/03/2019
Peer-reviewed
Oui
Volume
15
Numéro
641
Pages
536-541
Langue
français
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Diffuse interstitial lung disease (ILD) is one of the most frequent extra-articular manifestation of rheumatoid arthritis (RA) and is an important factor of morbidity and mortality. However, the physiopathological mechanisms underlying RA-associated ILD remain poorly understood, and disease management is difficult in the absence of effective treatments and international guidelines. The recent identification of genetic variants and mutations similar to those observed in idiopathic pulmonary fibrosis (IPF), a disease affecting exclusively the lung, provides new insights into the understanding of RA-associated ILD. Furthermore, new antifibrotic drugs approved for the treatment of IPF, including pirfenidone and nintedanib, could also prove to be effective for RA-associated ILD. Studies are ongoing to confirm this hypothesis.
Mots-clé
Arthritis, Rheumatoid/complications, Arthritis, Rheumatoid/genetics, Arthritis, Rheumatoid/therapy, Humans, Idiopathic Pulmonary Fibrosis/genetics, Idiopathic Pulmonary Fibrosis/therapy, Lung Diseases, Interstitial/genetics, Lung Diseases, Interstitial/therapy, Treatment Outcome
Pubmed
Création de la notice
12/03/2019 16:03
Dernière modification de la notice
20/08/2019 14:15
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