"Hit the primary": A paradigm shift in the treatment of metastatic prostate cancer?

Détails

ID Serval
serval:BIB_3021B314D44B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
"Hit the primary": A paradigm shift in the treatment of metastatic prostate cancer?
Périodique
Critical Reviews In Oncology/hematology
Auteur(s)
Arcangeli S., Zilli T., De Bari B., Alongi F.
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
97
Pages
231-237
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublishDocument Type: Review
Résumé
Patients with metastatic prostate cancer (PC) represent a heterogeneous group with survival rates varying between 13 and 75 months. The current standard treatment in this setting is hormonal therapy, with or without docetaxel-based chemotherapy. In the era of individualized medicine, however, maximizing treatment options, especially in long-term surviving patients with limited disease burden, is of capital importance. Emerging data, mainly from retrospective surgical series, show survival benefits in men diagnosed with metastatic PC following definitive therapy for the prostate. Whether the irradiation of primary tumor in a metastatic disease might improve the therapeutic ratio in association with systemic treatments remains investigational. In this scenario, modern radiation therapy (RT) can play a significant role owing to its intrinsic capability to act as a more general immune response modifier, as well as to the potentially better toxicity profile compared to surgery. Preclinical data, clinical experience, and challenges in local treatment in de novo metastatic PC are reviewed and discussed.
Pubmed
Web of science
Création de la notice
19/02/2016 20:11
Dernière modification de la notice
20/08/2019 13:14
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