Biochemical effects of prolonged renin inhibition in marmosets

Details

Serval ID
serval:BIB_301C2DEE2DC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biochemical effects of prolonged renin inhibition in marmosets
Journal
Journal of Hypertension
Author(s)
Wood  J. M., Jobber  R. A., Baum  H. P., de Gasparo  M., Nussberger  J.
ISSN
0263-6352 (Print)
Publication state
Published
Issued date
08/1989
Volume
7
Number
8
Pages
615-8
Notes
Journal Article --- Old month value: Aug
Abstract
The renin inhibitor CGP 29,287 was administered continuously for 7 days (30 mg/kg per day, intraperitoneally, via osmotic minipumps) to normotensive marmosets fed a low-salt diet. As a control, another group of marmosets was given vehicle only. After 7 days of treatment, the mean arterial blood pressure of the CGP 29,287-treated marmosets was significantly lowered by about 23 mmHg. Plasma immunoreactive total and active renin were increased 10- and sevenfold, respectively, whereas plasma renin activity (PRA) was reduced by 95%. Plasma angiotensin II (Ang II) and aldosterone were also reduced (by 97 and 85%, respectively). Serum angiotensin converting enzyme activity was unchanged and there were no differences in plasma concentrations of electrolytes, urea or creatinine between CGP 29,287-treated and control marmosets. These results indicate that although renin release is markedly stimulated after continuous administration of a renin inhibitor for 7 days, the formation of Ang II and aldosterone, the active hormones of the renin-angiotensin system, is substantially reduced.
Keywords
Aldosterone/biosynthesis Angiotensin II/biosynthesis Animals Blood Pressure/*drug effects Callithrix Heart Rate/drug effects Infusion Pumps *Oligopeptides Renin/administration & dosage/*antagonists & inhibitors/blood/pharmacology
Pubmed
Web of science
Create date
05/03/2008 16:40
Last modification date
20/08/2019 13:14
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