Article: article from journal or magazin.
Advanced electron microscopy in life sciences. Finding the place of interest
Imaging & Microscopy
In the past decades, high-throughput technologies were developed with the aim to unravel the secret of life. In the genomics project many genomes were sequenced, including the human genome. We ended up with a lot of data but no real clue if and at what point of time a certain illness will manifest, finally not the gene but the presence or absence of the responsible protein will be decisive. Therefore, proteomics came into reach and focus of research. Again we ended up with a wealth of data but still the final answer cannot be found. Finally, not only the presence of the protein is important but also its modification and, even more importantly, its location, whether it is 'just' stored in a cell or whether it is active at the place the where action is needed. The future will therefore be structomics.
Correlative Microscopy, Focussed Ion Beam (FIB), Cryo-Fixation, Freeze-Substitution
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