Follow-up of 32 hypothalamo-hypopituitary patients treated with pulsatile gonadotropin-releasing hormone or human menopausal gonadotropin

Details

Serval ID
serval:BIB_2F94AE0273F4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Follow-up of 32 hypothalamo-hypopituitary patients treated with pulsatile gonadotropin-releasing hormone or human menopausal gonadotropin
Journal
Gynecological Endocrinology
Author(s)
Marci  R., Dessole  S., Senn  A., De Grandi  P., Germond  M.
ISSN
0951-3590 (Print)
Publication state
Published
Issued date
12/1999
Volume
13
Number
6
Pages
375-81
Notes
Journal Article --- Old month value: Dec
Abstract
In a clinical retrospective study, a follow-up of hypothalamo-amenorrheic patients treated firstly with gonadotropin-releasing hormone (GnRH) pump stimulation and secondly with human menopausal gonadotropin (hMG) was performed. Thirty-two hypothalamo-amenorrheic patients, 24-38 years old, were submitted to 103 GnRH stimulation cycles. Seven, with polycystic ovaries (PCO) on ultrasound, were stimulated with hMG after one or several unsuccessful pump cycles. Ovulation was confirmed by a luteinizing hormone (LH) surge or triggered by human chorionic gonadotropin in 80 out of 103 cycles (77.7%/cycle) leading to 62 timed sexual intercourses and 17 intrauterine inseminations (IUI). Twenty-one pregnancies (26.3%/cycle) terminated in eight abortions (38.1%/pregnancy) and 13 deliveries (40.6%/patient). hMG stimulation, in the seven PCO patients (six IVF, one IUI), led to four additional deliveries in three patients. Five patients became pregnant spontaneously after pump failure (n = 2) or unsuccessful IVF (n = 3). Combining all cycles, 17 deliveries were obtained in 16 patients. No case of ovarian hyperstimulation syndrome (OHSS) was observed. GnRH is an efficient and safe treatment of hypothalamo-amenorrheic-induced anovulation. Following GnRH or hMG ovarian stimulation, spontaneous ovulation and conception may be restored in certain hypothalamo-amenorrheic patients.
Keywords
Adult Amenorrhea/*etiology Anovulation/*drug therapy/*etiology Female Fertilization in Vitro Gonadotropin-Releasing Hormone/administration & dosage/*therapeutic use Humans Hypothalamic Diseases/*complications Male Menotropins/*therapeutic use Periodicity Pregnancy Retrospective Studies
Pubmed
Web of science
Create date
25/01/2008 15:39
Last modification date
20/08/2019 13:14
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