Global Genetic Networks and the Genotype-to-Phenotype Relationship.

Détails

ID Serval
serval:BIB_2F6F7F80AA32
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Global Genetic Networks and the Genotype-to-Phenotype Relationship.
Périodique
Cell
Auteur(s)
Costanzo M., Kuzmin E., van Leeuwen J., Mair B., Moffat J., Boone C., Andrews B.
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
177
Numéro
1
Pages
85-100
Langue
anglais
Résumé
Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation of allelic combinations of genes underlying inherited traits. In this Review, we discuss how large-scale analyses in model systems have illuminated the general principles and phenotypic impact of genetic interactions. We focus on studies in budding yeast, including the mapping of a global genetic network. We emphasize how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.
Mots-clé
General Biochemistry, Genetics and Molecular Biology
Pubmed
Web of science
Création de la notice
21/03/2019 17:57
Dernière modification de la notice
20/08/2019 14:13
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