Respiratory symptoms do not reflect functional impairment in early CF lung disease.
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_2F084B7CBAA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Respiratory symptoms do not reflect functional impairment in early CF lung disease.
Journal
Journal of cystic fibrosis
Working group(s)
SCILD, and BILD, study group
ISSN
1873-5010 (Electronic)
ISSN-L
1569-1993
Publication state
Published
Issued date
11/2021
Peer-reviewed
Oui
Volume
20
Number
6
Pages
957-964
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.
We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.
We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.
We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.
We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.
We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.
We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.
Keywords
Case-Control Studies, Cystic Fibrosis/physiopathology, Female, Humans, Infant, Male, Predictive Value of Tests, Prospective Studies, Respiratory Function Tests, Respiratory Rate, Cohort study, Cystic fibrosis, Healthy controls, Infancy, Respiratory symptoms
Pubmed
Web of science
Open Access
Yes
Create date
15/06/2021 15:11
Last modification date
06/02/2024 7:21
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