Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_2ED594423FCC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB/c mice.
Périodique
Journal of Immunology
Auteur(s)
Ronet C., Voigt H., Himmelrich H., Doucey M.A., Hauyon-La Torre Y., Revaz-Breton M., Tacchini-Cottier F., Bron C., Louis J., Launois P.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
180
Numéro
7
Pages
4825-4835
Langue
anglais
Résumé
B lymphocytes are considered to play a minimal role in host defense against Leishmania major. In this study, the contribution of B cells to susceptibility to infection with different strains of L. major was investigated in BALB/c mice lacking mature B cells due to the disruption of the IgM transmembrane domain (microMT). Whereas BALB/c microMT remained susceptible to infection with L. major IR173 and IR75, they were partially resistant to infection with L. major LV39. Adoptive transfer of naive B cells into BALB/c microMT mice before infection restored susceptibility to infection with L. major LV39, demonstrating a role for B cells in susceptibility to infection with this parasite. In contrast, adoptive transfer of B cells that express an IgM/IgD specific for hen egg lysozyme (HEL), an irrelevant Ag, did not restore disease progression in BALB/c microMT mice infected with L. major LV39. This finding was likely due to the inability of HEL Tg B cells to internalize and present Leishmania Ags to specific T cells. Furthermore, specific Ig did not contribute to disease progression as assessed by transfer of immune serum in BALB/c microMT mice. These data suggest that direct Ag presentation by specific B cells and not Ig effector functions is involved in susceptibility of BALB/c mice to infection with L. major LV39.
Mots-clé
Adoptive Transfer, Animals, Antibodies, Protozoan/immunology, Antigen-Presenting Cells/immunology, B-Lymphocytes/immunology, Cell Differentiation/immunology, Cells, Cultured, Disease Susceptibility/immunology, Immunity, Innate/immunology, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Mice, Mice, Inbred BALB C, Phenotype, Th2 Cells/immunology
Pubmed
Web of science
Création de la notice
29/01/2009 23:14
Dernière modification de la notice
20/08/2019 14:13
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