Therapeutic drug monitoring of targeted anticancer therapy.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Public
Version: Final published version
ID Serval
serval:BIB_2E88575DAD1C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Therapeutic drug monitoring of targeted anticancer therapy.
Périodique
Biomarkers In Medicine
Auteur(s)
Decosterd L.A., Widmer N., Zaman K., Cardoso E., Buclin T., Csajka C.
ISSN
1752-0371 (Electronic)
ISSN-L
1752-0363
Statut éditorial
Publié
Date de publication
09/2015
Peer-reviewed
Oui
Volume
9
Numéro
9
Pages
887-893
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
New oral targeted anticancer therapies are revolutionizing cancer treatment by transforming previously deadly malignancies into chronically manageable conditions. Nevertheless, drug resistance, persistence of cancer stem cells, and adverse drug effects still limit their ability to stabilize or cure malignant diseases in the long term. Response to targeted anticancer therapy is influenced by tumor genetics and by variability in drug concentrations. However, despite a significant inter-patient pharmacokinetic variability, targeted anticancer drugs are essentially licensed at fixed doses. Their therapeutic use could however be optimized by individualization of their dosage, based on blood concentration measurements via the therapeutic drug monitoring (TDM). TDM can increase the probability of therapeutic responses to targeted anticancer therapies, and would help minimize the risk of major adverse reactions.
Mots-clé
Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/pharmacology, Drug Monitoring/methods, Humans, Molecular Targeted Therapy/methods, Neoplasms/drug therapy, Neoplasms/metabolism
Pubmed
Web of science
Création de la notice
17/09/2015 9:52
Dernière modification de la notice
20/08/2019 14:13
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