Systematic review and meta-analysis of risk factors for survival after lung metastasectomy in colorectal cancer patients

Details

Serval ID
serval:BIB_2E6EB7670D35
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Systematic review and meta-analysis of risk factors for survival after lung metastasectomy in colorectal cancer patients
Title of the conference
99th Annual Congress of the Swiss Society of Surgery
Author(s)
Gonzalez M., Poncet A., Combescure C., Robert J., Ris H.B., Gervaz P.
Address
Davos, Switzerland, June 20-22, 2012
ISBN
0007-1323
Publication state
Published
Issued date
2012
Volume
99
Series
British Journal of Surgery
Pages
22
Language
english
Notes
Document Type: Meeting Abstract
Abstract
Objective: Resection of lung metastases (LM) from colorectal cancer (CRC)¦is increasingly performed with a curative intent.Most series report small groups¦of patients, and it is currently not possible to identify those CRC patients who¦may benefit the most of surgical management. It is clinically relevant to assess¦risk factors for prolonged survival after this type of procedures.¦Methods: A meta analysis of 24 series published between 2000 and 2011¦which focused on surgical management of LM from CRC and included more¦than 40 patients each, with or without prior resection of in transit liver¦metastases. Random effects were calculated for five variables considered as¦potential prognostic factors.¦Results: A total of 2815 patients who underwent surgery with a curative¦intent were considered in this analysis. Four parameters were associated with¦a decreased survival: 1) a short disease-free interval between primary tumor¦resection and development of LM (HR = 1·59, 95% CI 1·27-1·98); 2) multiple¦LM (HR = 2·04, 95%CI 1·72-2·41); 3) positive hilar/mediastinal lymph nodes¦(HR = 1·65, 95% CI 1·35-2·02); and 4) a high prethoracotomy CEA value (HR¦=1·91, 95% CI 1·57-2·32). By comparison, a history of resected liver metastases¦(HR = 1·36, 95% CI 0·92-2·03) did not achieve statistical significance.¦Conclusion: Risk factors for poor clinical outcome after surgery for lung¦metastases in CRC patients include: 1) synchronous lung metastases; 2) high¦pre-thoracotomy CEA; 3) hilar nodes involvement; and 4) multiple pulmonary¦lesions.
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Create date
19/06/2012 19:12
Last modification date
20/08/2019 13:13
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