Dual-energy computed tomography in calcium pyrophosphate deposition: initial clinical experience.

Détails

ID Serval
serval:BIB_2E4C35B01ECA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dual-energy computed tomography in calcium pyrophosphate deposition: initial clinical experience.
Périodique
Osteoarthritis and cartilage
Auteur(s)
Pascart T., Norberciak L., Legrand J., Becce F., Budzik J.F.
ISSN
1522-9653 (Electronic)
ISSN-L
1063-4584
Statut éditorial
Publié
Date de publication
09/2019
Peer-reviewed
Oui
Volume
27
Numéro
9
Pages
1309-1314
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To determine the dual-energy computed tomography (DECT) attenuation properties of meniscal calcifications in calcium pyrophosphate deposition (CPPD) in vivo, and assess whether DECT was able to discriminate meniscal CPP deposits from calcium hydroxyapatite (HA) in subchondral and trabecular bone.
Patients with clinical suspicion of crystal-related arthropathy (gout and/or CPPD) and knee DECT scans were retrospectively assigned to CPPD (n = 19) or control (n = 21) groups depending on the presence/absence of chondrocalcinosis on DECT. Two observers drew standardized regions of interest (ROI) in meniscal calcifications, non-calcified menisci, as well as subchondral and trabecular bone. Five DECT parameters were obtained: CT numbers (HU) at 80 and 140 kV, dual-energy index (DEI), electron density (ρ <sub>e</sub> ), and effective atomic number (Z <sub>eff</sub> ). The four different knee structures were compared within/between patients and controls using linear mixed models, adjusting for confounders.
Meniscal calcifications (n = 89) in CPPD patients had mean ± SD CT numbers at 80 and 140 kV of 257 ± 64 and 201 ± 48 HU, respectively; with a DEI of 0.023 ± 0.007, and ρ <sub>e</sub> and Z <sub>eff</sub> of 140 ± 35 and 8.8 ± 0.3, respectively. Meniscal CPP deposits were readily distinguished from calcium HA in subchondral and trabecular bone (p ≤ 0.001), except at 80 kV separately (p = 0.74). Z <sub>eff</sub> and ρ <sub>e</sub> both significantly differed between CPP deposits and calcium HA in subchondral and trabecular bone (p < 0.0001).
This proof-of-concept study shows that DECT has the potential to discriminate meniscal CPP deposits from calcium HA in subchondral and trabecular bone in vivo, paving the way for the non-invasive biochemical signature assessment of intra- and juxta-articular calcium crystal deposits.
Mots-clé
Calcium hydroxyapatite, Calcium pyrophosphate deposition, Chondrocalcinosis, Dual-energy computed tomography, Knee, Meniscus
Pubmed
Web of science
Création de la notice
18/06/2019 17:29
Dernière modification de la notice
10/10/2019 6:10
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