Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements.

Détails

ID Serval
serval:BIB_2E39ACAC2E29
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements.
Périodique
Cell
Auteur(s)
Hernandez N., Weiner A.M.
ISSN
0092-8674[print], 0092-8674[linking]
Statut éditorial
Publié
Date de publication
10/1986
Volume
47
Numéro
2
Pages
249-258
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Résumé
U1 and U2 snRNAs are thought to be transcribed by RNA polymerase II. A conserved sequence known as the 3' box is located just downstream from the snRNA coding region and directs formation of the 3' end of pre-U1 and pre-U2 snRNA. We show here that a U1 or U2 promoter containing an intact snRNA enhancer is required for the U1 3' box to function efficiently. Promoters for genes encoding mRNAs cannot substitute for the snRNA promoter. Thus snRNAs must be transcribed by a specialized transcription complex that differs from transcription complexes synthesizing mRNAs. Moreover, in contrast to polyadenylated and nonpolyadenylated mRNAs, the 3' ends of pre-snRNAs must be generated either by termination of transcription, or by an RNA processing event intimately coupled to transcription.
Mots-clé
Chromosome Deletion, Enhancer Elements, Genetic, Gene Expression Regulation, Genes, Genes, Regulator, Humans, Mutation, Promoter Regions, Genetic, RNA Caps, RNA Processing, Post-Transcriptional, RNA, Small Nuclear/genetics, Transcription, Genetic
Pubmed
Web of science
Création de la notice
21/01/2008 17:34
Dernière modification de la notice
20/08/2019 14:12
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