Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.

Winkler, T.W.; Rasheed, H.; Teumer, A.; Gorski, M.; Rowan, B.X.; Stanzick, K.J.; Thomas, L.F.; Tin, A.; Hoppmann, A.; Chu, A.Y.; Tayo, B.; Thio, CHL; Cusi, D.; Chai, J.F.; Sieber, K.B.; Horn, K.; Li, M.; Scholz, M.; Cocca, M.; Wuttke, M.; van der Most, P.J.; Yang, Q.; Ghasemi, S.; Nutile, T.; Li, Y.; Pontali, G.; Günther, F.; Dehghan, A.; Correa, A.; Parsa, A.; Feresin, A.; de Vries, APJ; Zonderman, A.B.; Smith, A.V.; Oldehinkel, A.J.; De Grandi, A.; Rosenkranz, A.R.; Franke, A.; Teren, A.; Metspalu, A.; Hicks, A.A.; Morris, A.P.; Tönjes, A.; Morgan, A.; Podgornaia, A.I.; Peters, A.; Körner, A.; Mahajan, A.; Campbell, A.; Freedman, B.I.; Spedicati, B.; Ponte, B.; Schöttker, B.; Brumpton, B.; Banas, B.; Krämer, B.K.; Jung, B.; Åsvold, B.O.; Smith, B.H.; Ning, B.; Penninx, BWJH; Vanderwerff, B.R.; Psaty, B.M.; Kammerer, C.M.; Langefeld, C.D.; Hayward, C.; Spracklen, C.N.; Robinson-Cohen, C.; Hartman, C.A.; Lindgren, C.M.; Wang, C.; Sabanayagam, C.; Heng, C.K.; Lanzani, C.; Khor, C.C.; Cheng, C.Y.; Fuchsberger, C.; Gieger, C.; Shaffer, C.M.; Schulz, C.A.; Willer, C.J.; Chasman, D.I.; Gudbjartsson, D.F.; Ruggiero, D.; Toniolo, D.; Czamara, D.; Porteous, D.J.; Waterworth, D.M.; Mascalzoni, D.; Mook-Kanamori, D.O.; Reilly, D.F.; Daw, E.W.; Hofer, E.; Boerwinkle, E.; Salvi, E.; Bottinger, E.P.; Tai, E.S.; Catamo, E.; Rizzi, F.; Guo, F.; Rivadeneira, F.; Guilianini, F.; Sveinbjornsson, G.; Ehret, G.; Waeber, G.; Biino, G.; Girotto, G.; Pistis, G.; Nadkarni, G.N.; Delgado, G.E.; Montgomery, G.W.; Snieder, H.; Campbell, H.; White, H.D.; Gao, H.; Stringham, H.M.; Schmidt, H.; Li, H.; Brenner, H.; Holm, H.; Kirsten, H.; Kramer, H.; Rudan, I.; Nolte, I.M.; Tzoulaki, I.; Olafsson, I.; Martins, J.; Cook, J.P.; Wilson, J.F.; Halbritter, J.; Felix, J.F.; Divers, J.; Kooner, J.S.; Lee, J.J.; O'Connell, J.; Rotter, J.I.; Liu, J.; Xu, J.; Thiery, J.; Ärnlöv, J.; Kuusisto, J.; Jakobsdottir, J.; Tremblay, J.; Chambers, J.C.; Whitfield, J.B.; Gaziano, J.M.; Marten, J.; Coresh, J.; Jonas, J.B.; Mychaleckyj, J.C.; Christensen, K.; Eckardt, K.U.; Mohlke, K.L.; Endlich, K.; Dittrich, K.; Ryan, K.A.; Rice, K.M.; Taylor, K.D.; Ho, K.; Nikus, K.; Matsuda, K.; Strauch, K.; Miliku, K.; Hveem, K.; Lind, L.; Wallentin, L.; Yerges-Armstrong, L.M.; Raffield, L.M.; Phillips, L.S.; Launer, L.J.; Lyytikäinen, L.P.; Lange, L.A.; Citterio, L.; Klaric, L.; Ikram, M.A.; Ising, M.; Kleber, M.E.; Francescatto, M.; Concas, M.P.; Ciullo, M.; Piratsu, M.; Orho-Melander, M.; Laakso, M.; Loeffler, M.; Perola, M.; de Borst, M.H.; Gögele, M.; Bianca, M.; Lukas, M.A.; Feitosa, M.F.; Biggs, M.L.; Wojczynski, M.K.; Kavousi, M.; Kanai, M.; Akiyama, M.; Yasuda, M.; Nauck, M.; Waldenberger, M.; Chee, M.L.; Chee, M.L.; Boehnke, M.; Preuss, M.H.; Stumvoll, M.; Province, M.A.; Evans, M.K.; O'Donoghue, M.L.; Kubo, M.; Kähönen, M.; Kastarinen, M.; Nalls, M.A.; Kuokkanen, M.; Ghanbari, M.; Bochud, M.; Josyula, N.S.; Martin, N.G.; Tan, NYQ; Palmer, N.D.; Pirastu, N.; Schupf, N.; Verweij, N.; Hutri-Kähönen, N.; Mononen, N.; Bansal, N.; Devuyst, O.; Melander, O.; Raitakari, O.T.; Polasek, O.; Manunta, P.; Gasparini, P.; Mishra, P.P.; Sulem, P.; Magnusson, PKE; Elliott, P.; Ridker, P.M.; Hamet, P.; Svensson, P.O.; Joshi, P.K.; Kovacs, P.; Pramstaller, P.P.; Rossing, P.; Vollenweider, P.; van der Harst, P.; Dorajoo, R.; Sim, RZH; Burkhardt, R.; Tao, R.; Noordam, R.; Mägi, R.; Schmidt, R.; de Mutsert, R.; Rueedi, R.; van Dam, R.M.; Carroll, R.J.; Gansevoort, R.T.; Loos, RJF; Felicita, S.C.; Sedaghat, S.; Padmanabhan, S.; Freitag-Wolf, S.; Pendergrass, S.A.; Graham, S.E.; Gordon, S.D.; Hwang, S.J.; Kerr, S.M.; Vaccargiu, S.; Patil, S.B.; Hallan, S.; Bakker, SJL; Lim, S.C.; Lucae, S.; Vogelezang, S.; Bergmann, S.; Corre, T.; Ahluwalia, T.S.; Lehtimäki, T.; Boutin, T.S.; Meitinger, T.; Wong, T.Y.; Bergler, T.; Rabelink, T.J.; Esko, T.; Haller, T.; Thorsteinsdottir, U.; Völker, U.; Foo, VHX; Salomaa, V.; Vitart, V.; Giedraitis, V.; Gudnason, V.; Jaddoe, VWV; Huang, W.; Zhang, W.; Wei, W.B.; Kiess, W.; März, W.; Koenig, W.; Lieb, W.; Gao, X.; Sim, X.; Wang, Y.X.; Friedlander, Y.; Tham, Y.C.; Kamatani, Y.; Okada, Y.; Milaneschi, Y.; Yu, Z.; Stark, K.J.; Stefansson, K.; Böger, C.A.; Hung, A.M.; Kronenberg, F.; Köttgen, A.; Pattaro, C.; Heid, I.M.

doi:10.1038/s42003-022-03448-z

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.

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License: CC BY 4.0

Serval ID

serval:BIB_2E29F39E6E69

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.

Journal

Communications biology

Author(s)

Winkler T.W., Rasheed H., Teumer A., Gorski M., Rowan B.X., Stanzick K.J., Thomas L.F., Tin A., Hoppmann A., Chu A.Y., Tayo B., Thio CHL, Cusi D., Chai J.F., Sieber K.B., Horn K., Li M., Scholz M., Cocca M., Wuttke M., van der Most P.J., Yang Q., Ghasemi S., Nutile T., Li Y., Pontali G., Günther F., Dehghan A., Correa A., Parsa A., Feresin A., de Vries APJ, Zonderman A.B., Smith A.V., Oldehinkel A.J., De Grandi A., Rosenkranz A.R., Franke A., Teren A., Metspalu A., Hicks A.A., Morris A.P., Tönjes A., Morgan A., Podgornaia A.I., Peters A., Körner A., Mahajan A., Campbell A., Freedman B.I., Spedicati B., Ponte B., Schöttker B., Brumpton B., Banas B., Krämer B.K., Jung B., Åsvold B.O., Smith B.H., Ning B., Penninx BWJH, Vanderwerff B.R., Psaty B.M., Kammerer C.M., Langefeld C.D., Hayward C., Spracklen C.N., Robinson-Cohen C., Hartman C.A., Lindgren C.M., Wang C., Sabanayagam C., Heng C.K., Lanzani C., Khor C.C., Cheng C.Y., Fuchsberger C., Gieger C., Shaffer C.M., Schulz C.A., Willer C.J., Chasman D.I., Gudbjartsson D.F., Ruggiero D., Toniolo D., Czamara D., Porteous D.J., Waterworth D.M., Mascalzoni D., Mook-Kanamori D.O., Reilly D.F., Daw E.W., Hofer E., Boerwinkle E., Salvi E., Bottinger E.P., Tai E.S., Catamo E., Rizzi F., Guo F., Rivadeneira F., Guilianini F., Sveinbjornsson G., Ehret G., Waeber G., Biino G., Girotto G., Pistis G., Nadkarni G.N., Delgado G.E., Montgomery G.W., Snieder H., Campbell H., White H.D., Gao H., Stringham H.M., Schmidt H., Li H., Brenner H., Holm H., Kirsten H., Kramer H., Rudan I., Nolte I.M., Tzoulaki I., Olafsson I., Martins J., Cook J.P., Wilson J.F., Halbritter J., Felix J.F., Divers J., Kooner J.S., Lee J.J., O'Connell J., Rotter J.I., Liu J., Xu J., Thiery J., Ärnlöv J., Kuusisto J., Jakobsdottir J., Tremblay J., Chambers J.C., Whitfield J.B., Gaziano J.M., Marten J., Coresh J., Jonas J.B., Mychaleckyj J.C., Christensen K., Eckardt K.U., Mohlke K.L., Endlich K., Dittrich K., Ryan K.A., Rice K.M., Taylor K.D., Ho K., Nikus K., Matsuda K., Strauch K., Miliku K., Hveem K., Lind L., Wallentin L., Yerges-Armstrong L.M., Raffield L.M., Phillips L.S., Launer L.J., Lyytikäinen L.P., Lange L.A., Citterio L., Klaric L., Ikram M.A., Ising M., Kleber M.E., Francescatto M., Concas M.P., Ciullo M., Piratsu M., Orho-Melander M., Laakso M., Loeffler M., Perola M., de Borst M.H., Gögele M., Bianca M., Lukas M.A., Feitosa M.F., Biggs M.L., Wojczynski M.K., Kavousi M., Kanai M., Akiyama M., Yasuda M., Nauck M., Waldenberger M., Chee M.L., Chee M.L., Boehnke M., Preuss M.H., Stumvoll M., Province M.A., Evans M.K., O'Donoghue M.L., Kubo M., Kähönen M., Kastarinen M., Nalls M.A., Kuokkanen M., Ghanbari M., Bochud M., Josyula N.S., Martin N.G., Tan NYQ, Palmer N.D., Pirastu N., Schupf N., Verweij N., Hutri-Kähönen N., Mononen N., Bansal N., Devuyst O., Melander O., Raitakari O.T., Polasek O., Manunta P., Gasparini P., Mishra P.P., Sulem P., Magnusson PKE, Elliott P., Ridker P.M., Hamet P., Svensson P.O., Joshi P.K., Kovacs P., Pramstaller P.P., Rossing P., Vollenweider P., van der Harst P., Dorajoo R., Sim RZH, Burkhardt R., Tao R., Noordam R., Mägi R., Schmidt R., de Mutsert R., Rueedi R., van Dam R.M., Carroll R.J., Gansevoort R.T., Loos RJF, Felicita S.C., Sedaghat S., Padmanabhan S., Freitag-Wolf S., Pendergrass S.A., Graham S.E., Gordon S.D., Hwang S.J., Kerr S.M., Vaccargiu S., Patil S.B., Hallan S., Bakker SJL, Lim S.C., Lucae S., Vogelezang S., Bergmann S., Corre T., Ahluwalia T.S., Lehtimäki T., Boutin T.S., Meitinger T., Wong T.Y., Bergler T., Rabelink T.J., Esko T., Haller T., Thorsteinsdottir U., Völker U., Foo VHX, Salomaa V., Vitart V., Giedraitis V., Gudnason V., Jaddoe VWV, Huang W., Zhang W., Wei W.B., Kiess W., März W., Koenig W., Lieb W., Gao X., Sim X., Wang Y.X., Friedlander Y., Tham Y.C., Kamatani Y., Okada Y., Milaneschi Y., Yu Z., Stark K.J., Stefansson K., Böger C.A., Hung A.M., Kronenberg F., Köttgen A., Pattaro C., Heid I.M.

Working group(s)

Lifelines cohort study, DiscovEHR/MyCode study, VA Million Veteran Program

Contributor(s)

Thio CHL, van der Most P.J., de Borst M.H., Ho K., Josyula N.S., Pendergrass S.A., Rowan B.X., Robinson-Cohen C., Gaziano J.M., Phillips L.S., Tao R., Hung A.M.

ISSN

2399-3642 (Electronic)

ISSN-L

2399-3642

Publication state

Published

Issued date

13/06/2022

Peer-reviewed

Oui

Volume

Number

Pages

580

Language

english

Notes

Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: epublish

Abstract

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (n <sub>DM</sub> = 178,691, n <sub>noDM</sub> = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.

Keywords

Creatinine, Diabetes Mellitus, Diabetic Nephropathies/genetics, Genome-Wide Association Study, Glomerular Filtration Rate/genetics, Humans, Kidney

URN

urn:nbn:ch:serval-BIB_2E29F39E6E697

OAI-PMH

oai:serval.unil.ch:BIB_2E29F39E6E69

DOI

10.1038/s42003-022-03448-z

Pubmed

35697829

Web of science

000810675200002