Perirhinal and parahippocampal cortices of the macaque monkey: Intrinsic projections and interconnections

Details

Serval ID
serval:BIB_2E1DE3B907BD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Perirhinal and parahippocampal cortices of the macaque monkey: Intrinsic projections and interconnections
Journal
Journal of Comparative Neurology
Author(s)
Lavenex P., Suzuki W.A., Amaral D.G.
ISSN
0021-9967 (Print)
1096-9861 (Electronic)
ISSN-L
0021-9967
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
472
Number
3
Pages
371-394
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Abstract
We investigated the topographic and laminar organization of the intrinsic projections and interconnections of the macaque monkey perirhinal and parahippocampal cortices. Discrete anterograde tracer injections placed at various rostrocaudal and mediolateral levels in these cortices revealed extensive associational connections both within and between the perirhinal and parahippocampal cortices. Areas 35, 36rm, 36rl, 36cm, and 36cl are highly interconnected, whereas area 36d (encompassing the dorsal portion of the medial temporal pole) shares only modest connections with the rest of the perirhinal cortex. Areas TH, TFm, and TFl of the parahippocampal cortex also share an extensive network of associational connections that tend to be heaviest within a given subdivision. Area 36c of the perirhinal cortex is the main interface between the perirhinal and parahippocampal cortices. Its heaviest connections are with area 36r and the anterior aspect of area TF. The laminar organization of all these connections is typical of associational projections. Anterograde tracer experiments revealed that these projections are distributed through both deep and superficial layers, although heavier projections are directed toward the superficial layers. Results of retrograde tracer experiments suggested that the projections from caudal areas (36c or TF) to area 36r are of the feedforward type, whereas the projections from areas 36r and 36c to area TF are of the feedback type. These findings suggest that the perirhinal cortex is at a higher level than the parahippocampal cortex in the hierarchy of associational cortices. We discuss the functional implications of the organization of these extensive networks of intrinsic, associational projections.
Keywords
Animals, Brain Mapping, Entorhinal Cortex/anatomy & histology, Entorhinal Cortex/physiology, Female, Macaca fascicularis, Male, Neural Pathways/anatomy & histology, Neural Pathways/physiology, Parahippocampal Gyrus/anatomy & histology, Parahippocampal Gyrus/physiology, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate/metabolism
Pubmed
Create date
13/10/2014 18:51
Last modification date
20/08/2019 14:12
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