Article: article from journal or magazin.
Immune response in mice that lack the interferon-gamma receptor.
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Animals, Antibodies, Viral/blood, Immunity, Immunoglobulin G/blood, Interferon-gamma/physiology, Listeriosis/immunology, Lymphocyte Subsets, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Receptors, Interferon/genetics, Receptors, Interferon/physiology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Helper-Inducer/immunology, Vaccinia/immunology, Virus Diseases/immunology, Virus Replication
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