Article: article from journal or magazin.
Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis.
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Intravenous magnesium has been reported to improve postoperative pain; however, the evidence is inconsistent. The objective of this quantitative systematic review is to evaluate whether or not the peri-operative administration of intravenous magnesium can reduce postoperative pain. Twenty-five trials comparing magnesium with placebo were identified. Independent of the mode of administration (bolus or continuous infusion), peri-operative magnesium reduced cumulative intravenous morphine consumption by 24.4% (mean difference: 7.6 mg, 95% CI -9.5 to -5.8 mg; p < 0.00001) at 24 h postoperatively. Numeric pain scores at rest and on movement at 24 h postoperatively were reduced by 4.2 (95% CI -6.3 to -2.1; p < 0.0001) and 9.2 (95% CI -16.1 to -2.3; p = 0.009) out of 100, respectively. We conclude that peri-operative intravenous magnesium reduces opioid consumption, and to a lesser extent, pain scores, in the first 24 h postoperatively, without any reported serious adverse effects.
Acute Pain/prevention & control, Analgesics, Opioid/administration & dosage, Analgesics, Opioid/therapeutic use, Bradycardia/chemically induced, Bradycardia/epidemiology, Endpoint Determination, Female, Humans, Infusions, Intravenous, Injections, Intravenous, Magnesium Sulfate/administration & dosage, Magnesium Sulfate/adverse effects, Male, Morphine/administration & dosage, Morphine/therapeutic use, Pain Measurement/drug effects, Pain, Postoperative/prevention & control, Perioperative Care, Randomized Controlled Trials as Topic, Treatment Outcome
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