Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3.
Details
Serval ID
serval:BIB_2DD696A86A48
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Regulation of inflammation and protection against invasive pneumococcal infection by the long pentraxin PTX3.
Journal
eLife
ISSN
2050-084X (Electronic)
ISSN-L
2050-084X
Publication state
Published
Issued date
24/05/2023
Peer-reviewed
Oui
Volume
12
Pages
e78601
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Streptococcus pneumoniae is a major pathogen in children, elderly subjects, and immunodeficient patients. Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule (PRM) involved in resistance to selected microbial agents and in regulation of inflammation. The present study was designed to assess the role of PTX3 in invasive pneumococcal infection. In a murine model of invasive pneumococcal infection, PTX3 was strongly induced in non-hematopoietic (particularly, endothelial) cells. The IL-1β/MyD88 axis played a major role in regulation of the Ptx3 gene expression. Ptx3 <sup>-/-</sup> mice presented more severe invasive pneumococcal infection. Although high concentrations of PTX3 had opsonic activity in vitro, no evidence of PTX3-enhanced phagocytosis was obtained in vivo. In contrast, Ptx3-deficient mice showed enhanced recruitment of neutrophils and inflammation. Using P-selectin-deficient mice, we found that protection against pneumococcus was dependent upon PTX3-mediated regulation of neutrophil inflammation. In humans, PTX3 gene polymorphisms were associated with invasive pneumococcal infections. Thus, this fluid-phase PRM plays an important role in tuning inflammation and resistance against invasive pneumococcal infection.
Keywords
Animals, Mice, Inflammation/metabolism, Neutrophils/metabolism, Phagocytosis, Pneumococcal Infections/genetics, Pneumococcal Infections/metabolism, Streptococcus pneumoniae, P-selectin, Pentraxin 3, endothelial cells, immunology, infectious disease, inflammation, microbiology, mouse, neutrophils
Pubmed
Web of science
Open Access
Yes
Create date
30/05/2023 11:01
Last modification date
08/08/2024 7:31