How to Recruit the Correct RNA Polymerase? Lessons from snRNA Genes.

Détails

ID Serval
serval:BIB_2D60ACFF38B5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
How to Recruit the Correct RNA Polymerase? Lessons from snRNA Genes.
Périodique
Trends in Genetics
Auteur(s)
Dergai O., Hernandez N.
ISSN
0168-9525 (Print)
ISSN-L
0168-9525
Statut éditorial
Publié
Date de publication
06/2019
Peer-reviewed
Oui
Volume
35
Numéro
6
Pages
457-469
Langue
anglais
Résumé
Nuclear eukaryotic genomes are transcribed by three related RNA polymerases (Pol), which transcribe distinct gene sets. Specific Pol recruitment is achieved through selective core promoter recognition by basal transcription factors (TFs). Transcription by an inappropriate Pol appears to be rare and to generate mostly unstable products. A collection of short noncoding RNA genes [for example, small nuclear RNA (snRNA) or 7SK RNA genes], which play essential roles in processes such as maturation of RNA molecules or control of Pol II transcription elongation, possess highly similar core promoters, and yet are transcribed for some by Pol II and for others by Pol III as a result of small promoter differences. Here we discuss the mechanisms of selective Pol recruitment to such promoters.
Mots-clé
RNA polymerase, SNAPc, snRNA genes, transcription initiation
Pubmed
Web of science
Création de la notice
06/05/2019 17:09
Dernière modification de la notice
04/06/2019 6:26
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