Adherence to treatment in men with hypogonadotrophic hypogonadism.

Détails

ID Serval
serval:BIB_2D5AD6331898
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adherence to treatment in men with hypogonadotrophic hypogonadism.
Périodique
Clinical endocrinology
Auteur(s)
Dwyer A.A., Tiemensma J., Quinton R., Pitteloud N., Morin D.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
86
Numéro
3
Pages
377-383
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Men with congenital hypogonadotrophic hypogonadism (CHH) typically require lifelong hormonal therapy, and discontinuing treatment can have negative health consequences. Little is known about adherence to treatment or the psychosocial impact of CHH.
A sequential, multiple methods approach was used. A quantitative online survey assessed adherence to treatment, depressive symptoms and illness perceptions. Subsequently, qualitative focus groups explored patient-reported factors for adherence.
Adult men with CHH on at least 1 year of treatment were recruited internationally.
Adherence (Morisky medication adherence scale), depressive symptoms (Zung self-rating depression scale) and patient perception of CHH (revised illness perception questionnaire) were assessed in an online survey, and comparisons were made to reference groups. Patient focus group discussions were conducted and thematic analysis was employed to identify patient-reported factors for adherence.
In total, 101 men on long-term treatment were included (mean age 37 ± 11 years). Forty three percent (43/101) exhibited low medication adherence and a significantly elevated prevalence of mild, moderate or severe depressive symptoms (27%, 17%, 20%, respectively, all P < 0·001 vs reference population). Patients reported negative illness perceptions and significant psychosocial consequences. Focus group discussions (n = 3, 26 total patients) identified patient-, health professional- and healthcare system-related barriers as targets for improving adherence.
Congenital hypogonadotrophic hypogonadism men are challenged to adhere to long-term treatment. Poor adherence may contribute to adverse effects on bone, sexual and psychological health. The psychosocial morbidity of CHH is significant and appears to be underappreciated by healthcare providers.

Pubmed
Création de la notice
24/09/2016 10:42
Dernière modification de la notice
20/08/2019 13:12
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