Sensing of glucose in the brain.

Détails

ID Serval
serval:BIB_2D4773FC7904
Type
Partie de livre
Collection
Publications
Titre
Sensing of glucose in the brain.
Titre du livre
Appetite control
Auteur(s)
Thorens B.
Editeur
Springer-Verlag
Lieu d'édition
Berlin
ISBN
978-3-642-24715-6
Statut éditorial
Publié
Date de publication
2012
Editeur scientifique
Joost H.G.
Volume
209
Série
Handbook of experimental pharmacology
Pages
277-294
Langue
anglais
Résumé
The brain, and in particular the hypothalamus and brainstem, have been recognized for decades as important centers for the homeostatic control of feeding, energy expenditure, and glucose homeostasis. These structures contain neurons and neuronal circuits that may be directly or indirectly activated or inhibited by glucose, lipids, or amino acids. The detection by neurons of these nutrient cues may become deregulated, and possibly cause metabolic diseases such as obesity and diabetes. Thus, there is a major interest in identifying these neurons, how they respond to nutrients, the neuronal circuits they form, and the physiological function they control. Here I will review some aspects of glucose sensing by the brain. The brain is responsive to both hyperglycemia and hypoglycemia, and the glucose sensing cells involved are distributed in several anatomical sites that are connected to each other. These eventually control the activity of the sympathetic or parasympathetic nervous system, which regulates the function of peripheral organs such as liver, white and brown fat, muscle, and pancreatic islets alpha and beta cells. There is now evidence for an extreme diversity in the sensing mechanisms used, and these will be reviewed.
Pubmed
Création de la notice
25/01/2012 9:22
Dernière modification de la notice
20/08/2019 13:12
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